| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HD_2015 | dacA | HD_2015 | HD_2016 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | 0.561 |
| HD_2015 | rlpA | HD_2015 | HD_2017 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Possible rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.410 |
| dacA | HD_2015 | HD_2016 | HD_2015 | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | Conserved hypothetical protein; Belongs to the UPF0250 family. | 0.561 |
| dacA | mrdA | HD_2016 | HD_2020 | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.518 |
| dacA | mrdB | HD_2016 | HD_2019 | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.522 |
| dacA | rlmH | HD_2016 | HD_2022 | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | Conserved hypotheical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.537 |
| dacA | rlpA | HD_2016 | HD_2017 | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | Possible rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.572 |
| metG | rlpA | HD_1054 | HD_2017 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Possible rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.416 |
| metG | rsfS | HD_1054 | HD_2023 | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.508 |
| mltG | rlpA | HD_1932 | HD_2017 | Conserved hypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. | Possible rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.458 |
| mrdA | dacA | HD_2020 | HD_2016 | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | 0.518 |
| mrdA | mrdB | HD_2020 | HD_2019 | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.995 |
| mrdA | rlmH | HD_2020 | HD_2022 | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Conserved hypotheical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.800 |
| mrdA | rlpA | HD_2020 | HD_2017 | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Possible rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.620 |
| mrdA | rsfS | HD_2020 | HD_2023 | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.649 |
| mrdB | dacA | HD_2019 | HD_2016 | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | Penicillin-binding protein 5; D-alanyl-D-alanine carboxypeptidase fraction A; Belongs to the peptidase S11 family. | 0.522 |
| mrdB | mrdA | HD_2019 | HD_2020 | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | Penicillin binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. | 0.995 |
| mrdB | murA | HD_2019 | HD_0253 | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | UDP-N-Acetyllglucosamine- 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.716 |
| mrdB | rlmH | HD_2019 | HD_2022 | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | Conserved hypotheical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. | 0.752 |
| mrdB | rlpA | HD_2019 | HD_2017 | Rod-shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | Possible rare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. | 0.629 |