STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
degSOuter membrane stress sensor protease DegS; COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain. (353 aa)    
Predicted Functional Partners:
rseA
Sigma factor RpoE negative regulatory protein RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytop [...]
  
 
 0.947
rseP
Membrane-associated zinc metalloprotease; COG0750 Predicted membrane-associated Zn-dependent proteases 1.
 
  
 0.783
arcB
Aerobic respiration control sensor protein; COG1242 Predicted Fe-S oxidoreductase; putative Fe-S oxidoreductase.
  
  
 0.715
ompC
Outer membrane protein C.
  
 
 
 0.660
degQ
Outer membrane stress sensor protease DegQ serine protease; COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain; Belongs to the peptidase S1C family.
 
    
0.613
barA
Histidine kinase; Potential frameshift: common BLAST hit: gi|261822788|ref|YP_003260894.1| glycerate kinase; glycerate kinase.
  
  
 0.581
hisS
COG0124 Histidyl-tRNA synthetase.
  
  
 0.544
glnS
COG0008 Glutamyl- and glutaminyl-tRNA synthetases.
   
  
 0.536
yhcB
Putative cytochrome d ubiquinol oxidase subunit III (Cytochrome bd-I oxidase subunit III); COG3105 Uncharacterized protein conserved in bacteria.
 
     0.474
nfuA
Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
 
 0.424
Your Current Organism:
Sodalis pierantonius
NCBI taxonomy Id: 2342
Other names: C. Sodalis pierantonius str. SOPE, Candidatus Sodalis pierantonius str. SOPE, SOPE, Sitophilus oryzae endosymbiont, Sitophilus oryzae primary endosymbiont, Sitophilus oryzae principal endosymbiont, primary endosymbiont of Sitophilus oryzae
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