STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
poxBPyruvate dehydrogenase; Potential frameshift: common BLAST hit: gi|157369906|ref|YP_001477895.1| L-threonine aldolase; L-threonine aldolase; Belongs to the TPP enzyme family. (569 aa)    
Predicted Functional Partners:
ilvH
COG0440 Acetolactate synthase, small (regulatory) subunit.
 0.998
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.941
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.938
pykF
tRNA-Val; COG0534 Na+-driven multidrug efflux pump; Multi antimicrobial extrusion protein (Na(+)/drug antiporter) MATE family of MDR efflux pumps; Belongs to the pyruvate kinase family.
  
 0.916
pykA
COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.916
aceE
Pyruvate dehydrogenase subunit E1; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.909
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.894
ilvM
COG3978 Acetolactate synthase (isozyme II), small (regulatory) subunit.
  
 0.863
thrA
Aspartokinase / Homoserine dehydrogenase; COG0527 Aspartokinases; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.856
katE
Hydroperoxidase II; Serves to protect cells from the toxic effects of hydrogen peroxide.
   
 0.829
Your Current Organism:
Sodalis pierantonius
NCBI taxonomy Id: 2342
Other names: C. Sodalis pierantonius str. SOPE, Candidatus Sodalis pierantonius str. SOPE, SOPE, Sitophilus oryzae endosymbiont, Sitophilus oryzae primary endosymbiont, Sitophilus oryzae principal endosymbiont, primary endosymbiont of Sitophilus oryzae
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