Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Acid_0761PFAM: Uroporphyrinogen III synthase HEM4; KEGG: rba:RB7803 uroporphyrinogen III synthase, uroporhyrinogen decarboxylase. (250 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.993
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.983
Acid_0181
TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; KEGG: aae:aq_207 uroporphyrin-III C-methyltransferase.
 
 
 0.933
Acid_3181
uroporphyrinogen-III C-methyltransferase / uroporphyrinogen-III synthase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: sat:SYN_02272 uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase.
 
 
 0.932
Acid_0188
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: rba:RB7803 uroporphyrinogen III synthase, uroporhyrinogen decarboxylase.
  
  
 
0.906
Acid_2458
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: aba:Acid345_4300 porphobilinogen synthase; Belongs to the ALAD family.
  
 
 0.805
Acid_7668
PFAM: GAF domain protein; KEGG: pca:Pcar_2313 putative GAF sensor protein.
      0.795
Acid_2751
PFAM: TrkA-N domain protein; TrkA-C domain protein; Ion transport 2 domain protein,; KEGG: aba:Acid345_3283 TrkA-N.
  
    0.676
Acid_0159
PFAM: amino acid-binding ACT domain protein; KEGG: mka:MK0609 predicted metabolic regulator containing the ACT domain.
   
    0.668
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.663
Your Current Organism:
Solibacter usitatus
NCBI taxonomy Id: 234267
Other names: Acidobacteriaceae bacterium Ellin6076, Acidobacterium sp. Ellin6076, C. Solibacter usitatus Ellin6076, Candidatus Solibacter usitatus Ellin6076, Solibacter usitatus Ellin6076, bacterium Ellin6076
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.