Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Acid_4002methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (174 aa)    
Predicted Functional Partners:
Acid_4001
PFAM: helix-turn-helix- domain containing protein, AraC type; HhH-GPD family protein; Ada, metal-binding domain protein; AlkA domain protein; KEGG: ade:Adeh_0970 transcriptional regulator, AraC family.
  
 0.968
Acid_3576
Domain of unknown function DUF1730; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; domain of unknown function DUF1730; KEGG: aba:Acid345_4182 4Fe-4S ferredoxin, iron-sulfur binding.
      0.901
Acid_6307
DNA-3-methyladenine glycosylase II; PFAM: HhH-GPD family protein; KEGG: gvi:gll2018 probable DNA-3-methyladenine glycosylase.
 
  
 0.737
Acid_4009
DNA-O6-methylguanine--protein-cysteine S-methyltransferase / Transcriptional regulator Ada; TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: helix-turn-helix- domain containing protein, AraC type; methylated-DNA-[protein]-cysteine S-methyltransferase; Ada, metal-binding domain protein; methylguanine DNA methyltransferase, ribonuclease domain protein; KEGG: hch:HCH_05579 adenosine deaminase.
 
  
0.531
Acid_3999
PFAM: protein of unknown function DUF1469; KEGG: tfu:Tfu_2992 hypothetical protein.
       0.442
Acid_4000
Hypothetical protein.
       0.437
mntH
Mn2+/Fe2+ transporter, NRAMP family; H(+)-stimulated, divalent metal cation uptake system. Belongs to the NRAMP family.
  
  
 0.432
Acid_3998
PFAM: Late embryogenesis abundant protein; KEGG: mlo:mlr9697 hypothetical protein.
       0.416
Your Current Organism:
Solibacter usitatus
NCBI taxonomy Id: 234267
Other names: Acidobacteriaceae bacterium Ellin6076, Acidobacterium sp. Ellin6076, C. Solibacter usitatus Ellin6076, Candidatus Solibacter usitatus Ellin6076, Solibacter usitatus Ellin6076, bacterium Ellin6076
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