Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Acid_4262PFAM: ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: aba:Acid345_0710 ATPase AAA-2. (392 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 0.934
Acid_1213
PFAM: ATP-dependent Clp protease adaptor protein ClpS; KEGG: rba:RB12137 hypothetical protein.
  
 
 0.780
Acid_7099
PFAM: heat shock protein Hsp20; KEGG: rxy:Rxyl_2320 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family.
 
 
 0.737
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.700
Acid_6319
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.700
Acid_2332
PFAM: heat shock protein Hsp20; KEGG: gsu:GSU0538 heat shock protein, HSP20 family; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.692
Acid_0977
KEGG: reu:Reut_A1752 putative heat-shock chaperone protein; Belongs to the heat shock protein 70 family.
  
 
 0.644
Acid_0981
PFAM: Heat shock protein 70; KEGG: bur:Bcep18194_B2544 molecular chaperone-like.
  
 
 0.644
Acid_5615
KEGG: mag:amb4304 molecular chaperone.
  
 
 0.644
Acid_6320
PFAM: Heat shock protein 70; KEGG: tma:TM0373 dnaK protein.
  
 
 0.644
Your Current Organism:
Solibacter usitatus
NCBI taxonomy Id: 234267
Other names: Acidobacteriaceae bacterium Ellin6076, Acidobacterium sp. Ellin6076, C. Solibacter usitatus Ellin6076, Candidatus Solibacter usitatus Ellin6076, Solibacter usitatus Ellin6076, bacterium Ellin6076
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