Acid_5383 protein (Solibacter usitatus) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

Acid_5383

Hypothetical protein; KEGG: aba:Acid345_1549 TonB-dependent receptor. (1098 aa)

Predicted Functional Partners:

Acid_7026

0.770

Acid_5078

0.765

Acid_1509

0.763

Acid_2218

0.756

Acid_1024

0.753

Acid_1568

0.723

Acid_1280

0.718

Acid_6238

0.718

Acid_5910

0.711

Acid_7266

0.708

Your Current Organism:

Solibacter usitatus

NCBI taxonomy Id: 234267
Other names: Acidobacteriaceae bacterium Ellin6076, Acidobacterium sp. Ellin6076, C. Solibacter usitatus Ellin6076, Candidatus Solibacter usitatus Ellin6076, Solibacter usitatus Ellin6076, bacterium Ellin6076

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Acid_1024	Acid_1280	KEGG: aba:Acid345_4220 hypothetical protein.	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	0.463
Acid_1024	Acid_1509	KEGG: aba:Acid345_4220 hypothetical protein.	KEGG: aba:Acid345_3322 hypothetical protein.	0.768
Acid_1024	Acid_1568	KEGG: aba:Acid345_4220 hypothetical protein.	KEGG: aba:Acid345_2141 hypothetical protein.	0.773
Acid_1024	Acid_2218	KEGG: aba:Acid345_4220 hypothetical protein.	KEGG: aba:Acid345_3561 hypothetical protein.	0.772
Acid_1024	Acid_5078	KEGG: aba:Acid345_4220 hypothetical protein.	KEGG: aba:Acid345_4447 hypothetical protein.	0.516
Acid_1024	Acid_5383	KEGG: aba:Acid345_4220 hypothetical protein.	Hypothetical protein; KEGG: aba:Acid345_1549 TonB-dependent receptor.	0.753
Acid_1024	Acid_5910	KEGG: aba:Acid345_4220 hypothetical protein.	PFAM: von Willebrand factor, type A; KEGG: aba:Acid345_2058 von Willebrand factor, type A.	0.769
Acid_1024	Acid_6238	KEGG: aba:Acid345_4220 hypothetical protein.	KEGG: aba:Acid345_3343 membrane protein.	0.702
Acid_1024	Acid_7026	KEGG: aba:Acid345_4220 hypothetical protein.	KEGG: ccr:CC0925 OmpA-related protein.	0.705
Acid_1024	Acid_7266	KEGG: aba:Acid345_4220 hypothetical protein.	PFAM: von Willebrand factor, type A; KEGG: aba:Acid345_3344 von Willebrand factor, type A.	0.764
Acid_1280	Acid_1024	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	KEGG: aba:Acid345_4220 hypothetical protein.	0.463
Acid_1280	Acid_1509	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	KEGG: aba:Acid345_3322 hypothetical protein.	0.701
Acid_1280	Acid_1568	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	KEGG: aba:Acid345_2141 hypothetical protein.	0.544
Acid_1280	Acid_2218	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	KEGG: aba:Acid345_3561 hypothetical protein.	0.668
Acid_1280	Acid_5383	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	Hypothetical protein; KEGG: aba:Acid345_1549 TonB-dependent receptor.	0.718
Acid_1280	Acid_5910	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	PFAM: von Willebrand factor, type A; KEGG: aba:Acid345_2058 von Willebrand factor, type A.	0.625
Acid_1280	Acid_7026	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	KEGG: ccr:CC0925 OmpA-related protein.	0.700
Acid_1280	Acid_7266	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	PFAM: von Willebrand factor, type A; KEGG: aba:Acid345_3344 von Willebrand factor, type A.	0.632
Acid_1509	Acid_1024	KEGG: aba:Acid345_3322 hypothetical protein.	KEGG: aba:Acid345_4220 hypothetical protein.	0.768
Acid_1509	Acid_1280	KEGG: aba:Acid345_3322 hypothetical protein.	TIGRFAM: TonB family protein; PFAM: Gram-negative tonB protein; KEGG: aba:Acid345_0148 TonB-like protein.	0.701

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Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.867

expected number of edges:

19

PPI enrichment p-value:

0.0241

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016558

Protein import into peroxisome matrix

5 of 23

2.55

4.1

1.33e-08

GO:0016560

Protein import into peroxisome matrix, docking

3 of 9

2.73

2.62

1.49e-05

GO:0046474

Glycerophospholipid biosynthetic process

5 of 169

1.68

2.03

1.49e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043337

CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity

3 of 3

3.21

2.82

8.01e-06

GO:0008808

Cardiolipin synthase activity

3 of 3

3.21

2.82

8.01e-06

GO:0005052

Peroxisome matrix targeting signal-1 binding

2 of 2

3.21

1.67

0.00096

GO:0008022

Protein C-terminus binding

2 of 4

2.91

1.49

0.0020

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005778

Peroxisomal membrane

5 of 57

2.15

3.24

1.95e-07

GO:0005779

Integral component of peroxisomal membrane

2 of 17

2.28

1.08

0.0099

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21968

Biosynthesis of maresins, and Synthesis of CL

6 of 17

2.76

6.02

3.18e-12

CL:21973

Synthesis of CL, and Biosynthesis of maresins

5 of 11

2.87

5.34

1.03e-10

CL:17276

Protein import into peroxisome matrix, and SCP2 sterol-binding domain

5 of 14

2.76

5.13

2.03e-10

CL:21974

Synthesis of CL, and Biosynthesis of maresins

3 of 6

2.91

3.08

2.26e-06

CL:21985

Mixed, incl. Synthesis of CL, and Gti1/Pac2 family

2 of 5

2.81

1.69

0.00083

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04146

Peroxisome

6 of 209

1.67

2.55

1.90e-07

map00564

Glycerophospholipid metabolism

5 of 200

1.61

2.04

6.33e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1482925

Acyl chain remodelling of PG

5 of 21

2.59

4.53

1.97e-09

MAP-1483076

Synthesis of CL

3 of 3

3.21

3.18

1.72e-06

MAP-1483206

Glycerophospholipid biosynthesis

5 of 150

1.73

2.24

5.04e-06

MAP-1483257

Phospholipid metabolism

5 of 203

1.6

1.91

1.76e-05

MAP-9033241

Peroxisomal protein import

6 of 317

1.49

1.9

4.69e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005778

Peroxisomal membrane

5 of 124

1.82

2.23

1.04e-05

GOCC:1990429

Peroxisomal importomer complex

2 of 2

3.21

1.82

0.00053

GOCC:0005779

Integral component of peroxisomal membrane

2 of 8

2.61

1.36

0.0033

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 5493

0.47

0.35

0.0086

GOCC:0005737

Cytoplasm

10 of 5560

0.47

0.35

0.0086

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13344

Haloacid dehalogenase-like hydrolase

3 of 6

2.91

2.41

3.98e-05

PF13242

HAD-hyrolase-like

3 of 12

2.61

2.14

0.00011

PF04757

Pex2 / Pex12 amino terminal region

2 of 6

2.73

1.13

0.0088

PF01066

CDP-alcohol phosphatidyltransferase

2 of 10

2.51

0.99

0.0155

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006353

HAD-superfamily hydrolase, subfamily IIA, CECR5

3 of 4

3.09

2.4

4.42e-05

IPR006357

HAD-superfamily hydrolase, subfamily IIA

3 of 6

2.91

2.35

5.31e-05

IPR024111

PEX5/PEX5L

2 of 2

3.21

1.28

0.0050

IPR017375

Peroxisome assembly protein 12

2 of 2

3.21

1.28

0.0050

IPR006845

Pex, N-terminal

2 of 6

2.73

1.02

0.0141

(more ...)

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