node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acid_0253 | Acid_1686 | Acid_0253 | Acid_1686 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | 0.966 |
Acid_0253 | Acid_2676 | Acid_0253 | Acid_2676 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | 0.971 |
Acid_0253 | Acid_3250 | Acid_0253 | Acid_3250 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: tte:TTE1574 cystathionine gamma-synthase. | 0.947 |
Acid_0253 | Acid_3332 | Acid_0253 | Acid_3332 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | 0.938 |
Acid_0253 | Acid_4184 | Acid_0253 | Acid_4184 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.968 |
Acid_0253 | Acid_5643 | Acid_0253 | Acid_5643 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; KEGG: aba:Acid345_1913 cystathionine gamma-synthase. | 0.954 |
Acid_0253 | Acid_7115 | Acid_0253 | Acid_7115 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: aba:Acid345_3426 homocysteine S-methyltransferase. | 0.994 |
Acid_0253 | metK | Acid_0253 | Acid_5274 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.966 |
Acid_1686 | Acid_0253 | Acid_1686 | Acid_0253 | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 0.966 |
Acid_1686 | Acid_2676 | Acid_1686 | Acid_2676 | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | 0.966 |
Acid_1686 | Acid_3332 | Acid_1686 | Acid_3332 | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | 0.966 |
Acid_1686 | Acid_4184 | Acid_1686 | Acid_4184 | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.943 |
Acid_1686 | Acid_7115 | Acid_1686 | Acid_7115 | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: aba:Acid345_3426 homocysteine S-methyltransferase. | 0.987 |
Acid_1686 | metK | Acid_1686 | Acid_5274 | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.926 |
Acid_2669 | Acid_4184 | Acid_2669 | Acid_4184 | PFAM: Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: mta:Moth_2116 corrinoid methyltransferase, Methanosarcina species. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.760 |
Acid_2669 | Acid_7115 | Acid_2669 | Acid_7115 | PFAM: Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: mta:Moth_2116 corrinoid methyltransferase, Methanosarcina species. | PFAM: methylenetetrahydrofolate reductase; homocysteine S-methyltransferase; KEGG: aba:Acid345_3426 homocysteine S-methyltransferase. | 0.981 |
Acid_2676 | Acid_0253 | Acid_2676 | Acid_0253 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: bja:bll5948 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase. | 0.971 |
Acid_2676 | Acid_1686 | Acid_2676 | Acid_1686 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | PFAM: S-adenosylmethionine synthetase; KEGG: dge:Dgeo_0287 methionine adenosyltransferase. | 0.966 |
Acid_2676 | Acid_3250 | Acid_2676 | Acid_3250 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: tte:TTE1574 cystathionine gamma-synthase. | 0.947 |
Acid_2676 | Acid_3332 | Acid_2676 | Acid_3332 | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | PFAM: Methionine synthase, vitamin-B12 independent; KEGG: sso:SSO0407 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase. | 0.929 |