STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HH_0328Conserved hypothetical protein; Similar to Campylobacter jejuni CJ1113. (267 aa)    
Predicted Functional Partners:
pgk
3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
       0.829
HH_0329
Hypothetical protein; May become fused with HH0330 due to slipped strand mispairing.
       0.584
hypC
Hydrogenase isoenzymes formation protein HypC; Involved in the maturation of [NiFe] hydrogenases. Involved in the biosynthesis of the Fe(CN)(2)CO cofactor.
       0.537
hypB
Hydrogenase expression/formation protein HypB; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. Exhibits a low intrinsic GTPase activity, which is essential for nickel insertion; Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.
       0.537
hypF
Transcriptional regulatory protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
       0.537
HH_0321
Conserved hypothetical protein; Possible helicase subunit.
       0.444
hypD
Hydrogenase isoenzymes formation protein; Belongs to the HypD family.
       0.444
HH_0323
Conserved hypothetical protein; Similar to Helicobacter pylori putative lipopolysaccharide biosynthesis protein HP0805.
       0.444
hypE
Hydrogenase isoenzymes formation protein.
       0.421
HH_0330
Hypothetical protein; May become fused with HH0329 due to slipped strand mispairing.
       0.419
Your Current Organism:
Helicobacter hepaticus
NCBI taxonomy Id: 235279
Other names: H. hepaticus ATCC 51449, Helicobacter hepaticus ATCC 51449, Helicobacter hepaticus str. ATCC 51449
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.