node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GK0277 | ezrA | GK0277 | GK2798 | Hypothetical conserved protein. | Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. | 0.759 |
GK0277 | nadK1 | GK0277 | GK0830 | Hypothetical conserved protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.574 |
GK0827 | GK0828 | GK0827 | GK0828 | Hypothetical conserved protein. | Hypothetical conserved protein; Belongs to the UPF0738 family. | 0.586 |
GK0827 | GK0829 | GK0827 | GK0829 | Hypothetical conserved protein. | Hypothetical conserved protein. | 0.428 |
GK0827 | ezrA | GK0827 | GK2798 | Hypothetical conserved protein. | Septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. | 0.734 |
GK0827 | nadK1 | GK0827 | GK0830 | Hypothetical conserved protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.574 |
GK0828 | GK0827 | GK0828 | GK0827 | Hypothetical conserved protein; Belongs to the UPF0738 family. | Hypothetical conserved protein. | 0.586 |
GK0828 | GK0829 | GK0828 | GK0829 | Hypothetical conserved protein; Belongs to the UPF0738 family. | Hypothetical conserved protein. | 0.576 |
GK0828 | nadK1 | GK0828 | GK0830 | Hypothetical conserved protein; Belongs to the UPF0738 family. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.613 |
GK0829 | GK0827 | GK0829 | GK0827 | Hypothetical conserved protein. | Hypothetical conserved protein. | 0.428 |
GK0829 | GK0828 | GK0829 | GK0828 | Hypothetical conserved protein. | Hypothetical conserved protein; Belongs to the UPF0738 family. | 0.576 |
GK0829 | nadK1 | GK0829 | GK0830 | Hypothetical conserved protein. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.851 |
cobB1 | cobB2 | GK1437 | GK1653 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.913 |
cobB1 | nadD | GK1437 | GK2522 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.924 |
cobB1 | nadE | GK1437 | GK2596 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.922 |
cobB1 | nadK1 | GK1437 | GK0830 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.913 |
cobB1 | nadK2 | GK1437 | GK2792 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Hypothetical conserved protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.913 |
cobB2 | cobB1 | GK1653 | GK1437 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.913 |
cobB2 | nadD | GK1653 | GK2522 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.924 |
cobB2 | nadE | GK1653 | GK2596 | Transcriptional regulator (Sir2 family); NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. | 0.922 |