node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA74250.1 | SFA98790.1 | SAMN04489723_101135 | SAMN04489723_103112 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Allosteric NADP-dependent malic enzyme. | 0.919 |
SFA74250.1 | SFB21112.1 | SAMN04489723_101135 | SAMN04489723_105282 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.602 |
SFA74250.1 | SFB31219.1 | SAMN04489723_101135 | SAMN04489723_10775 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Citrate synthase; Belongs to the citrate synthase family. | 0.962 |
SFA74250.1 | SFB45875.1 | SAMN04489723_101135 | SAMN04489723_11161 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | 0.875 |
SFA74250.1 | SFB55865.1 | SAMN04489723_101135 | SAMN04489723_12017 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 2-oxoisovalerate dehydrogenase E1 component. | 0.875 |
SFA74250.1 | rpoC | SAMN04489723_101135 | SAMN04489723_10279 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.409 |
SFA74250.1 | sucC | SAMN04489723_101135 | SAMN04489723_10831 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.716 |
SFA98790.1 | SFA74250.1 | SAMN04489723_103112 | SAMN04489723_101135 | Allosteric NADP-dependent malic enzyme. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.919 |
SFA98790.1 | SFB21112.1 | SAMN04489723_103112 | SAMN04489723_105282 | Allosteric NADP-dependent malic enzyme. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.926 |
SFA98790.1 | SFB31219.1 | SAMN04489723_103112 | SAMN04489723_10775 | Allosteric NADP-dependent malic enzyme. | Citrate synthase; Belongs to the citrate synthase family. | 0.935 |
SFA98790.1 | SFB44006.1 | SAMN04489723_103112 | SAMN04489723_11094 | Allosteric NADP-dependent malic enzyme. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.945 |
SFA98790.1 | SFB45875.1 | SAMN04489723_103112 | SAMN04489723_11161 | Allosteric NADP-dependent malic enzyme. | Pyruvate/2-oxoglutarate/acetoin dehydrogenase complex, dehydrogenase (E1) component. | 0.977 |
SFA98790.1 | SFB55865.1 | SAMN04489723_103112 | SAMN04489723_12017 | Allosteric NADP-dependent malic enzyme. | 2-oxoisovalerate dehydrogenase E1 component. | 0.977 |
SFA98790.1 | fumC | SAMN04489723_103112 | SAMN04489723_11356 | Allosteric NADP-dependent malic enzyme. | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.943 |
SFA98790.1 | mdh | SAMN04489723_103112 | SAMN04489723_12048 | Allosteric NADP-dependent malic enzyme. | Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. | 0.944 |
SFA98790.1 | rpoC | SAMN04489723_103112 | SAMN04489723_10279 | Allosteric NADP-dependent malic enzyme. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.949 |
SFA98790.1 | sucC | SAMN04489723_103112 | SAMN04489723_10831 | Allosteric NADP-dependent malic enzyme. | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.919 |
SFB21112.1 | SFA74250.1 | SAMN04489723_105282 | SAMN04489723_101135 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.602 |
SFB21112.1 | SFA98790.1 | SAMN04489723_105282 | SAMN04489723_103112 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Allosteric NADP-dependent malic enzyme. | 0.926 |
SFB21112.1 | SFB31219.1 | SAMN04489723_105282 | SAMN04489723_10775 | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | Citrate synthase; Belongs to the citrate synthase family. | 0.416 |