node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA87959.1 | SFA92707.1 | SAMN04489723_102138 | SAMN04489723_102346 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.731 |
SFA87959.1 | SFB08311.1 | SAMN04489723_102138 | SAMN04489723_104113 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.693 |
SFA87959.1 | SFB54213.1 | SAMN04489723_102138 | SAMN04489723_11851 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent helicase HepA. | 0.896 |
SFA87959.1 | SFB59809.1 | SAMN04489723_102138 | SAMN04489723_12717 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | SNF2 family N-terminal domain-containing protein. | 0.896 |
SFA87959.1 | SFB61411.1 | SAMN04489723_102138 | SAMN04489723_13414 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.731 |
SFA87959.1 | thyA | SAMN04489723_102138 | SAMN04489723_10764 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.796 |
SFA92707.1 | SFA87959.1 | SAMN04489723_102346 | SAMN04489723_102138 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.731 |
SFA92707.1 | SFB08311.1 | SAMN04489723_102346 | SAMN04489723_104113 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.983 |
SFA92707.1 | thyA | SAMN04489723_102346 | SAMN04489723_10764 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.734 |
SFB08311.1 | SFA87959.1 | SAMN04489723_104113 | SAMN04489723_102138 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.693 |
SFB08311.1 | SFA92707.1 | SAMN04489723_104113 | SAMN04489723_102346 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.983 |
SFB08311.1 | SFB08339.1 | SAMN04489723_104113 | SAMN04489723_104114 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Protein of unknown function. | 0.647 |
SFB08311.1 | SFB26160.1 | SAMN04489723_104113 | SAMN04489723_106163 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA-binding transcriptional regulator YhcF, GntR family. | 0.531 |
SFB08311.1 | SFB54213.1 | SAMN04489723_104113 | SAMN04489723_11851 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | ATP-dependent helicase HepA. | 0.570 |
SFB08311.1 | SFB57582.1 | SAMN04489723_104113 | SAMN04489723_12248 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Putative holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. | 0.741 |
SFB08311.1 | SFB59809.1 | SAMN04489723_104113 | SAMN04489723_12717 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | SNF2 family N-terminal domain-containing protein. | 0.570 |
SFB08311.1 | SFB61411.1 | SAMN04489723_104113 | SAMN04489723_13414 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.983 |
SFB08311.1 | pdxH | SAMN04489723_104113 | SAMN04489723_104112 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.688 |
SFB08311.1 | thyA | SAMN04489723_104113 | SAMN04489723_10764 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.544 |
SFB08339.1 | SFB08311.1 | SAMN04489723_104114 | SAMN04489723_104113 | Protein of unknown function. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.647 |