node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFA73182.1 | clpB | SAMN04489723_10191 | SAMN04489723_102198 | Molecular chaperone HtpG. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.614 |
SFA73182.1 | dnaK | SAMN04489723_10191 | SAMN04489723_12216 | Molecular chaperone HtpG. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |
SFA73182.1 | groL | SAMN04489723_10191 | SAMN04489723_107234 | Molecular chaperone HtpG. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.857 |
SFA73182.1 | groS | SAMN04489723_10191 | SAMN04489723_107233 | Molecular chaperone HtpG. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.697 |
SFA73182.1 | grpE | SAMN04489723_10191 | SAMN04489723_102183 | Molecular chaperone HtpG. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.718 |
SFA73182.1 | hslU | SAMN04489723_10191 | SAMN04489723_105176 | Molecular chaperone HtpG. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.722 |
SFA73182.1 | hslV | SAMN04489723_10191 | SAMN04489723_106103 | Molecular chaperone HtpG. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.734 |
SFB39988.1 | clpB | SAMN04489723_10925 | SAMN04489723_102198 | Signal transduction histidine kinase. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.744 |
SFB39988.1 | clpP | SAMN04489723_10925 | SAMN04489723_1259 | Signal transduction histidine kinase. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.572 |
SFB39988.1 | dnaK | SAMN04489723_10925 | SAMN04489723_12216 | Signal transduction histidine kinase. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
SFB39988.1 | groL | SAMN04489723_10925 | SAMN04489723_107234 | Signal transduction histidine kinase. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.944 |
SFB39988.1 | groS | SAMN04489723_10925 | SAMN04489723_107233 | Signal transduction histidine kinase. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.701 |
SFB39988.1 | grpE | SAMN04489723_10925 | SAMN04489723_102183 | Signal transduction histidine kinase. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.772 |
SFB39988.1 | hslU | SAMN04489723_10925 | SAMN04489723_105176 | Signal transduction histidine kinase. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.729 |
SFB39988.1 | hslV | SAMN04489723_10925 | SAMN04489723_106103 | Signal transduction histidine kinase. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.737 |
clpB | SFA73182.1 | SAMN04489723_102198 | SAMN04489723_10191 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Molecular chaperone HtpG. | 0.614 |
clpB | SFB39988.1 | SAMN04489723_102198 | SAMN04489723_10925 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Signal transduction histidine kinase. | 0.744 |
clpB | clpP | SAMN04489723_102198 | SAMN04489723_1259 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.956 |
clpB | dnaK | SAMN04489723_102198 | SAMN04489723_12216 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.974 |
clpB | groL | SAMN04489723_102198 | SAMN04489723_107234 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.623 |