node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFB28031.1 | SFB45827.1 | SAMN04489723_106253 | SAMN04489723_11154 | Cystathionine beta-lyase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.756 |
SFB28031.1 | SFB45835.1 | SAMN04489723_106253 | SAMN04489723_11155 | Cystathionine beta-lyase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.821 |
SFB28031.1 | SFB45844.1 | SAMN04489723_106253 | SAMN04489723_11156 | Cystathionine beta-lyase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.852 |
SFB28031.1 | SFB47313.1 | SAMN04489723_106253 | SAMN04489723_11232 | Cystathionine beta-lyase. | Aspartate kinase. | 0.893 |
SFB28031.1 | SFB57371.1 | SAMN04489723_106253 | SAMN04489723_12229 | Cystathionine beta-lyase. | Cystathionine gamma-synthase. | 0.803 |
SFB28031.1 | ahcY | SAMN04489723_106253 | SAMN04489723_10384 | Cystathionine beta-lyase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.615 |
SFB28031.1 | metK | SAMN04489723_106253 | SAMN04489723_10178 | Cystathionine beta-lyase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.521 |
SFB28031.1 | metZ | SAMN04489723_106253 | SAMN04489723_105300 | Cystathionine beta-lyase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.607 |
SFB45827.1 | SFB28031.1 | SAMN04489723_11154 | SAMN04489723_106253 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine beta-lyase. | 0.756 |
SFB45827.1 | SFB45835.1 | SAMN04489723_11154 | SAMN04489723_11155 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.995 |
SFB45827.1 | SFB45844.1 | SAMN04489723_11154 | SAMN04489723_11156 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.996 |
SFB45827.1 | SFB47313.1 | SAMN04489723_11154 | SAMN04489723_11232 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aspartate kinase. | 0.971 |
SFB45827.1 | SFB57371.1 | SAMN04489723_11154 | SAMN04489723_12229 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Cystathionine gamma-synthase. | 0.756 |
SFB45827.1 | ahcY | SAMN04489723_11154 | SAMN04489723_10384 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.669 |
SFB45827.1 | gcvT | SAMN04489723_11154 | SAMN04489723_105125 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.851 |
SFB45827.1 | glyA | SAMN04489723_11154 | SAMN04489723_101185 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.931 |
SFB45827.1 | metK | SAMN04489723_11154 | SAMN04489723_10178 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.877 |
SFB45827.1 | metZ | SAMN04489723_11154 | SAMN04489723_105300 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.756 |
SFB45835.1 | SFB28031.1 | SAMN04489723_11155 | SAMN04489723_106253 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-lyase. | 0.821 |
SFB45835.1 | SFB45827.1 | SAMN04489723_11155 | SAMN04489723_11154 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.995 |