node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDM79815.1 | SDN84533.1 | SAMN05216498_0612 | SAMN05216498_0015 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.776 |
SDM79815.1 | gmk | SAMN05216498_0612 | SAMN05216498_1224 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.433 |
SDM79815.1 | thyA | SAMN05216498_0612 | SAMN05216498_2631 | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.821 |
SDN42315.1 | SDN67116.1 | SAMN05216498_2273 | SAMN05216498_2787 | Glutaredoxin. | Thioredoxin. | 0.837 |
SDN42315.1 | SDN84533.1 | SAMN05216498_2273 | SAMN05216498_0015 | Glutaredoxin. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.900 |
SDN42315.1 | SDN84552.1 | SAMN05216498_2273 | SAMN05216498_0016 | Glutaredoxin. | Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.541 |
SDN42315.1 | adk | SAMN05216498_2273 | SAMN05216498_0167 | Glutaredoxin. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.509 |
SDN42315.1 | ndk | SAMN05216498_2273 | SAMN05216498_2681 | Glutaredoxin. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.573 |
SDN42315.1 | ribBA | SAMN05216498_2273 | SAMN05216498_0341 | Glutaredoxin. | 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.740 |
SDN67116.1 | SDN42315.1 | SAMN05216498_2787 | SAMN05216498_2273 | Thioredoxin. | Glutaredoxin. | 0.837 |
SDN67116.1 | SDN84533.1 | SAMN05216498_2787 | SAMN05216498_0015 | Thioredoxin. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.720 |
SDN67116.1 | gmk | SAMN05216498_2787 | SAMN05216498_1224 | Thioredoxin. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.534 |
SDN67116.1 | ndk | SAMN05216498_2787 | SAMN05216498_2681 | Thioredoxin. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.676 |
SDN68573.1 | SDN84533.1 | SAMN05216498_2841 | SAMN05216498_0015 | Glutaredoxin. | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.841 |
SDN68573.1 | gmk | SAMN05216498_2841 | SAMN05216498_1224 | Glutaredoxin. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.546 |
SDN68573.1 | ndk | SAMN05216498_2841 | SAMN05216498_2681 | Glutaredoxin. | Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.507 |
SDN68573.1 | ribBA | SAMN05216498_2841 | SAMN05216498_0341 | Glutaredoxin. | 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.692 |
SDN84533.1 | SDM79815.1 | SAMN05216498_0015 | SAMN05216498_0612 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.776 |
SDN84533.1 | SDN42315.1 | SAMN05216498_0015 | SAMN05216498_2273 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Glutaredoxin. | 0.900 |
SDN84533.1 | SDN67116.1 | SAMN05216498_0015 | SAMN05216498_2787 | Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thioredoxin. | 0.720 |