node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDN38887.1 | SDN81013.1 | SAMN05216498_2153 | SAMN05216498_3127 | Threonine dehydratase. | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | 0.494 |
SDN38887.1 | glyA | SAMN05216498_2153 | SAMN05216498_0982 | Threonine dehydratase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.668 |
SDN38887.1 | trpA | SAMN05216498_2153 | SAMN05216498_2145 | Threonine dehydratase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.671 |
SDN38887.1 | trpB | SAMN05216498_2153 | SAMN05216498_2146 | Threonine dehydratase. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.766 |
SDN38887.1 | trpC | SAMN05216498_2153 | SAMN05216498_2148 | Threonine dehydratase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.713 |
SDN38887.1 | trpF | SAMN05216498_2153 | SAMN05216498_2147 | Threonine dehydratase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.677 |
SDN81013.1 | SDN38887.1 | SAMN05216498_3127 | SAMN05216498_2153 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Threonine dehydratase. | 0.494 |
SDN81013.1 | aroC | SAMN05216498_3127 | SAMN05216498_2679 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.998 |
SDN81013.1 | glyA | SAMN05216498_3127 | SAMN05216498_0982 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.415 |
SDN81013.1 | menF | SAMN05216498_3127 | SAMN05216498_0327 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.885 |
SDN81013.1 | trpA | SAMN05216498_3127 | SAMN05216498_2145 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.499 |
SDN81013.1 | trpC | SAMN05216498_3127 | SAMN05216498_2148 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.788 |
SDN81013.1 | trpD | SAMN05216498_3127 | SAMN05216498_2149 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Anthranilate phosphoribosyltransferase/anthranilate synthase/phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.847 |
SDN81013.1 | trpF | SAMN05216498_3127 | SAMN05216498_2147 | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.778 |
aroC | SDN81013.1 | SAMN05216498_2679 | SAMN05216498_3127 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase /chorismate mutase. | 0.998 |
aroC | menF | SAMN05216498_2679 | SAMN05216498_0327 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Menaquinone-specific isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.808 |
aroC | trpA | SAMN05216498_2679 | SAMN05216498_2145 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.770 |
aroC | trpB | SAMN05216498_2679 | SAMN05216498_2146 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.588 |
aroC | trpC | SAMN05216498_2679 | SAMN05216498_2148 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.768 |
aroC | trpD | SAMN05216498_2679 | SAMN05216498_2149 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate phosphoribosyltransferase/anthranilate synthase/phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.796 |