node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDO19785.1 | SDO60663.1 | SAMN04489756_102126 | SAMN04489756_11170 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | DnaJ domain-containing protein. | 0.464 |
SDO19785.1 | clpB | SAMN04489756_102126 | SAMN04489756_10387 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.778 |
SDO19785.1 | dnaJ | SAMN04489756_102126 | SAMN04489756_12136 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.464 |
SDO19785.1 | dnaK | SAMN04489756_102126 | SAMN04489756_12515 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.736 |
SDO19785.1 | groS | SAMN04489756_102126 | SAMN04489756_10322 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.422 |
SDO19785.1 | grpE | SAMN04489756_102126 | SAMN04489756_12135 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.702 |
SDO19785.1 | lon | SAMN04489756_102126 | SAMN04489756_10580 | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.479 |
SDO60663.1 | SDO19785.1 | SAMN04489756_11170 | SAMN04489756_102126 | DnaJ domain-containing protein. | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | 0.464 |
SDO60663.1 | clpB | SAMN04489756_11170 | SAMN04489756_10387 | DnaJ domain-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.668 |
SDO60663.1 | clpP | SAMN04489756_11170 | SAMN04489756_12120 | DnaJ domain-containing protein. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.500 |
SDO60663.1 | dnaK | SAMN04489756_11170 | SAMN04489756_12515 | DnaJ domain-containing protein. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.979 |
SDO60663.1 | groS | SAMN04489756_11170 | SAMN04489756_10322 | DnaJ domain-containing protein. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.676 |
SDO60663.1 | grpE | SAMN04489756_11170 | SAMN04489756_12135 | DnaJ domain-containing protein. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.883 |
SDO60663.1 | lon | SAMN04489756_11170 | SAMN04489756_10580 | DnaJ domain-containing protein. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.629 |
SDO89915.1 | clpB | SAMN04489756_12712 | SAMN04489756_10387 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.668 |
SDO89915.1 | clpP | SAMN04489756_12712 | SAMN04489756_12120 | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.625 |
clpB | SDO19785.1 | SAMN04489756_10387 | SAMN04489756_102126 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | HSP20 family protein; Belongs to the small heat shock protein (HSP20) family. | 0.778 |
clpB | SDO60663.1 | SAMN04489756_10387 | SAMN04489756_11170 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | DnaJ domain-containing protein. | 0.668 |
clpB | SDO89915.1 | SAMN04489756_10387 | SAMN04489756_12712 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease adaptor protein ClpS; Belongs to the ClpS family. | 0.668 |
clpB | clpP | SAMN04489756_10387 | SAMN04489756_12120 | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, protease subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.814 |