STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (295 aa)    
Predicted Functional Partners:
SDO45662.1
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.995
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
  
 0.958
SDO15095.1
Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
   
 
0.951
SDO17459.1
2-oxoisovalerate dehydrogenase E1 component.
  
 0.928
SDO18475.1
2-oxoisovalerate dehydrogenase E1 component.
  
 0.928
SDO63009.1
Aspartate kinase.
  
 
 0.914
SDO24146.1
Cystathionine gamma-synthase.
   
 0.911
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.908
SDO76261.1
Dehydratase family protein; Belongs to the IlvD/Edd family.
  
 
 0.905
ilvA
L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.875
Your Current Organism:
Cloacibacterium normanense
NCBI taxonomy Id: 237258
Other names: ATCC BAA-825, C. normanense, CCUG 46293, CIP 108613, Cloacibacterium normanense Allen et al. 2006, Cloacibacterium sp. IMET F, DSM 15886, cf. Bergeyella sp. CCUG 46293, strain NRS1
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