STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GAP6Amino-acid permease GAP6; Amino-acid permease with rather broad substrate specificity. Transports many amino acids including proline, methionine, leucine, valine, isoleucine, phenylalanine, tryptophan, threonine and tyrosine, but not basic ones (arginine) and citrulline. Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA. (568 aa)    
Predicted Functional Partners:
FCY23
Fcy23p.
      
 0.592
PGA33
Predicted GPI-anchored protein 33.
    
 0.520
PGA11
Predicted GPI-anchored protein 11.
      
 0.499
STP2
Transcriptional regulator STP2; Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS amino acid sensor system (including CSY1 and CSH3), becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor-regulated genes. Required for efficient alkalinization through the release of ammonia from the cells produced during the breakdown of amino acids, and subsequent switch to the hyph [...]
   
 
 0.486
TGL99
Tgl99p.
      
 0.479
DAL9
Dal9p.
   
 
 0.419
CaO19.2065
Allantoicase.
   
  
 0.412
DAL8
Dal8p.
    
 
 0.407
KAR5
Nuclear fusion protein KAR5; Required for nuclear membrane fusion during karyogamy. Belongs to the KAR5 family.
      
 0.400
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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