STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SCW11Putative glucan endo-1-beta-D-glucosidase. (506 aa)    
Predicted Functional Partners:
PGA38
Pga38p.
   
  
 0.957
CHT3
Chitinase 3; Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation.
   
  
 0.892
ENG1
Endo-1,3(4)-beta-glucanase 1; Endo-1,3(4)-beta-glucanase involved in the cell separation process. Plays no essential role in growth, nor is it involved in hyphal morphogenesis.
   
  
 0.799
FGR41
Filamentous growth regulator 41; Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth.
   
 0.795
DSE1
Protein DSE1; Involved in cell wall metabolism and required for the separation of the mother and daughter cells.
   
  
 0.728
CaO19.5267
Uncharacterized protein.
   
    0.679
CDC5
Serine/threonine-protein kinase.
   
 0.634
HHF1
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
  0.598
ACE2
Cell wall transcription factor ACE2; Transcription factor involved in the RAM (regulation of ACE2 transcription factor and polarized morphogenesis) signaling network that regulates polarized morphogenesis. Regulates expression of genes involved in cell separation such as CHT3, DSE1, and SCW11; or other cell wall genes such as ASH1, DSE4, PIR1, PRY2, and RME1. Required for regulation of morphogenesis, cell separation, adherence, biofilm formation, invasion, as well as virulence in a mouse model of infection.
   
 0.596
HOF1
Formin-binding protein.
   
  0.560
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.