STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLB3Lysophospholipase. (632 aa)    
Predicted Functional Partners:
CaO19.5426
PNPLA domain-containing protein.
     
 0.912
GDE1
Glycerophosphocholine phosphodiesterase GDE1; Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source. C.albicans can utilize GroPCho through transport and intracellular hydrolysis or through extracellular hydrolysis.
    
 0.904
LPT1
Lysophospholipid acyltransferase; Belongs to the membrane-bound acyltransferase family.
    
  0.902
HYR3
Hyphally regulated cell wall protein 3; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family.
      
 0.465
PGA52
GPI-anchored protein 52; Belongs to the PGA52 family.
   
 
 0.443
PLD1
Phospholipase.
      
 0.432
IFF4
Cell wall protein IFF4; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence. Plays a role in adherence to plastic and to host epithelial cells. Promotes the tissue fungal burden during murine vaginal candidiasis. Increases also susceptibility to neutrophil-mediated killing. Furthermore, contributes to the severity of hematogenously disseminated candidiasis in normal mice, but not in neutropenic mice.
   
  
 0.411
PGA26
Predicted GPI-anchored protein 26; GPI-anchored protein involved in proper cell wall integrity. Does not seem to be directly involved in the synthesis of the cell wall. Required for normal virulence in a mouse model of disseminated candidiasis.
   
  
 0.403
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.