STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SRR1Stress response regulator protein 1; Required for stress adaptation, morphogenesis and virulence. (282 aa)    
Predicted Functional Partners:
SKN7
Transcription factor SKN7; Transcription factor that is part of a SLN1-YPD1-SKN7 two- component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.
    
 0.827
CaO19.1314
RING-type domain-containing protein.
   
 0.666
CaO19.2515
ZZ-type domain-containing protein.
    
 0.606
UBI3
Ubiquitin-ribosomal 40S subunit protein S31 fusion protein.
    
 0.600
CaO19.6864
U-box domain-containing protein.
    
  0.594
SSK1
Oxidative stress response two-component system protein SSK1; Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with h [...]
   
 0.592
BMH1
14-3-3 protein homolog; Belongs to the 14-3-3 family.
   
 0.569
SST2
GTPase-activating protein.
   
 0.558
ADAEC
Adaecp.
   
 
 0.525
SCS7
Ceramide very long chain fatty acid hydroxylase; Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2; Belongs to the sterol desaturase family. SCS7 subfamily.
    
 
 0.518
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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