STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MRR2Multidrug resistance regulator 2; Transcription factor that controls the expression of CDR1, the major multidrug efflux pump. Required for yeast cell adherence to silicone substrate and plays a role in virulence. (710 aa)    
Predicted Functional Partners:
TAC1
Tac1p.
    
 
 0.645
WAR1
Transcriptional regulator WAR1; Transcription factor required for yeast cell adherence to silicone substrate. Plays a role in resistance to weak organic acids such as acetate and sorbate. Binds in vitro to a nitric oxide- responsive element (NORE) but seems not to be involved in response to nitrosative stress.
      
 0.617
UPC2
Sterol uptake control protein 2; Transcription factor involved in the regulation of ergosterol biosynthetic genes such as ERG2 and ERG11 through direct binding to sterol response elements (SREs) in the promoters. Binds also to its own promoter on 2 cis-acting elements to promote autoregulation. Regulates sterol uptake across the plasma membrane. Acts as a major regulator of ascorbic acid-induced response. Plays a role in the triggering of pyroptosis, an inflammasome-mediated programmed cell death pathway in macrophages, allowing macrophages escaping.
      
 0.600
CDR1
Pleiotropic ABC efflux transporter of multiple drugs CDR1; Pleiotropic ABC efflux transporter that confers resistance to numerous chemicals including anisomycin, cycloheximide, fluconazole, miconazole, ketoconazole, itriconazole, nystatin, terbinafine, amorolfine, brefeldin A, amphotericin B, fluphenazine, as well as estrogen. Plays a role in farnesol-induced apoptotic process through glutathione efflux activity. Mediates in-to-out transloaction of membrane phospholipids including aminophospholipids and thus regulates asymmetric distribution of phosphatidylethanolamine. Exhibits nucleo [...]
      
 0.593
LEU3
Leucine-responsive transcriptional regulator.
      
 0.503
UGA33
Uga33p.
      
 0.501
CaO19.2378
Uncharacterized protein.
      
 0.499
FGR27
Filamentous growth regulator 27; Transcription factor involved in yeast cell adherence to silicone substrate, filamentous growth, and biofilm formation.
      
 0.495
TRY2
Transcriptional regulator of yeast form adherence 2; Transcription factor required for yeast cell adherence to silicone substrate.
      
 0.493
ZCF28
Zcf28p.
    
 
 0.491
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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