STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CAN2Probable lysine/arginine permease CAN2; Probable permease for arginine and lysine. (568 aa)    
Predicted Functional Partners:
NCE103
Carbonic anhydrase; Catalyzes the reversible hydration of CO(2) to H(2)CO(3). The main role may be to provide inorganic carbon for the bicarbonate- dependent carboxylation reactions catalyzed by pyruvate carboxylase, acetyl-CoA carboxylase and carbamoyl-phosphate synthetase. Involved in protection against oxidative damage. Acts as a CO(2) chemosensor and induces CO(2)-mediated filamentation. Essential for pathological growth in niches where sufficient CO(2) is not supplied by the host. Necessary for white-to-opaque switching at low CO(2) concentrations.
      
 0.867
TPO4
Tpo4p.
    
 
 0.683
CaO19.3338
Uncharacterized protein.
    
 0.679
CaO19.7370
Cationic amino acid transporter.
      
 0.674
EHT1
Medium-chain fatty acid ethyl ester synthase/esterase.
      
 0.673
GAP2
General amino-acid permease GAP2; Amino-acid permease with broad substrate specificity. GAP2 is the only amino-acid permease with very broad substrate specificity, none of the other GAP permeases is able to transport such a variety of amino acids. GAP2 is also able to transport thialysine, and thus probably also lysine. Functions as a sensor via detection of some amino acids including methionine, leading to a rapid activation of trehalase, a downstream target of PKA ; Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.
  
 
0.653
PMA1
Plasma membrane ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.
   
 
 0.645
PIL1
Lipid-binding protein.
    
 0.599
CaO19.2065
Allantoicase.
      
 0.538
DAL4
Allantoin permease.
   
 
 0.524
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.