STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PGA30Cell wall protein PGA30; Component of the cell wall involved in virulence which plays a role in the relationship between C.albicans and the host. Belongs to the SRP1/TIP1 family. (277 aa)    
Predicted Functional Partners:
PGA4
1,3-beta-glucanosyltransferase PGA4; Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall biosynthesis and morphogenesis. Plays a key role in virulence.
    
 0.532
YWP1
Yeast-form wall Protein 1; Cell wall protein which plays an anti-adhesive role and promotes dispersal of yeast forms, which allows the organism to seek new sites for colonization.
   
 0.512
PGA45
Predicted GPI-anchored protein 45.
      
 0.506
PGA1
Predicted GPI-anchored protein 1; Plays a role in cell wall stability and rigidity. Required for normal adhesion to host cells and for adherence during biofilm formation. Necessary for proper oxidative stress response.
      
 0.501
SSR1
Covalently-linked cell wall protein 14; Beta-glucan associated cell wall protein involved in cell wall structure. May serve as cross-linking or coat-forming wall protein.
    
 0.498
PNS1
Protein PNS1; Probably involved in transport through the plasma membrane. Belongs to the CTL (choline transporter-like) family.
      
 0.471
PAM17
Presequence translocated-associated motor subunit PAM17, mitochondrial; Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.
    
 
 0.466
MYO2
Myosin 2; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 0.433
OSM2
Fumarate reductase.
   
 
 0.423
SAP98
Sap98p; Belongs to the peptidase A1 family.
    
 0.421
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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