STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HYR4Hyphally regulated cell wall protein 4; GPI-anchored cell wall protein involved in cell wall organization, hyphal growth, as well as in host-fungal interaction and virulence; Belongs to the HYR1/IFF family. (1225 aa)    
Predicted Functional Partners:
YWP1
Yeast-form wall Protein 1; Cell wall protein which plays an anti-adhesive role and promotes dispersal of yeast forms, which allows the organism to seek new sites for colonization.
    
 0.499
CaO19.6449
Uncharacterized protein.
   
 0.482
RIM9
pH-response regulator protein palI/RIM9; Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH; Belongs to the palI/RIM9 family.
      
 0.470
RBT1
Cell wall protein RTB1; GPI-anchored cell wall protein required for mating efficiency, biofilm formation, and virulence. Involved in normal disseminated infection, but not in intestinal colonization.
    
 0.454
CaO19.2200
L-type lectin-like domain-containing protein.
   
 0.454
ALS3
Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family.
    
 0.448
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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