Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ALS1 | CPH1 | Q5A8T4 | P43079 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. | 0.677 |
| ALS1 | ECE1 | Q5A8T4 | Q07730 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII). | 0.838 |
| ALS1 | EFG1 | Q5A8T4 | Q59X67 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | 0.913 |
| ALS1 | HWP1 | Q5A8T4 | P46593 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...] | 0.899 |
| ALS1 | HYR1 | Q5A8T4 | Q5AL03 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Hyphally regulated cell wall protein 1; GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through confering resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin- forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections. Belongs to the HYR1/IFF family. | 0.783 |
| ALS1 | SAP4 | Q5A8T4 | Q5A8N2 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Candidapepsin-4; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Activates host systemic immunity. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of [...] | 0.688 |
| ALS1 | SAP5 | Q5A8T4 | P43094 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Candidapepsin-5; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche usin [...] | 0.750 |
| ALS1 | SOD5 | Q5A8T4 | Q5AD07 | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | Cell surface Cu-only superoxide dismutase 5; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent. The unusual attributes of SOD5-like fungal proteins, including the absence of zinc and an open active site that readily captures extracellula [...] | 0.507 |
| ALS3 | CPH1 | Q59L12 | P43079 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. | 0.861 |
| ALS3 | ECE1 | Q59L12 | Q07730 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII). | 0.971 |
| ALS3 | EFG1 | Q59L12 | Q59X67 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | 0.886 |
| ALS3 | HWP1 | Q59L12 | P46593 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Hyphal wall protein 1; Major hyphal cell wall protein which plays a role of adhesin and is required for mating, normal hyphal development, cell-to-cell adhesive functions necessary for biofilm integrity, attachment to host, and virulence. Promotes interactions with host and bacterial molecules, thus leading to effective colonization within polymicrobial communities. Plays a crucial role in gastrointestinal colonization, in mucosal symptomatic and asymptomatic infections, in vaginitis, as well as in lethal oroesophageal candidiasis, caused by the combined action of fungal virulence fact [...] | 0.971 |
| ALS3 | HYR1 | Q59L12 | Q5AL03 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Hyphally regulated cell wall protein 1; GPI-anchored hyphal cell wall protein required for hyphal growth and virulence. Involved in innate immune cell evasion through confering resistance to neutrophil killing. Binds kininogen, the proteinaceous kinin precursor, and contributes to trigger the kinin- forming cascade on the cell surface. Production of kinins is often involved in the human host defense against microbial infections. Belongs to the HYR1/IFF family. | 0.948 |
| ALS3 | PLB2 | Q59L12 | A0A1D8PPS2 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Lysophospholipase. | 0.599 |
| ALS3 | SAP4 | Q59L12 | Q5A8N2 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Candidapepsin-4; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Activates host systemic immunity. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of [...] | 0.872 |
| ALS3 | SAP5 | Q59L12 | P43094 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Candidapepsin-5; Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. During infection, plays an important role in penetration into deeper tissues and interaction with host defense. Moreover, acts toward human hemoglobin though limited proteolysis to generate a variety of antimicrobial hemocidins, enabling to compete with the other microorganisms of the same physiological niche usin [...] | 0.872 |
| ALS3 | SOD5 | Q59L12 | Q5AD07 | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | Cell surface Cu-only superoxide dismutase 5; Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent. The unusual attributes of SOD5-like fungal proteins, including the absence of zinc and an open active site that readily captures extracellula [...] | 0.707 |
| CPH1 | ALS1 | P43079 | Q5A8T4 | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. | Agglutinin-like protein 1; Major cell surface adhesion protein which mediates both yeast-to-host tissue adherence and yeast aggregation. Acts as a downstream effector of the EFG1 regulatory pathway. Required for rapamycin-induced aggregation of C.albicans. Binds glycans and mediates adherence to endothelial and epithelial cells, thereby playing an important role in the pathogenesis of C.albicans infections. | 0.677 |
| CPH1 | ALS3 | P43079 | Q59L12 | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. | Agglutinin-like protein 3; Cell surface adhesion protein which mediates both yeast-to- host tissue adherence and yeast aggregation. Plays an important role in the biofilm formation and pathogenesis of C.albicans infections. Necessary for C.albicans to bind to N-cadherin on endothelial cells and E-cadherin on oral epithelial cells and subsequent endocytosis by these cells. During disseminated infection, mediates initial trafficking to the brain and renal cortex and contributes to fungal persistence in the kidneys. Belongs to the ALS family. | 0.861 |
| CPH1 | ECE1 | P43079 | Q07730 | Transcription factor CPH1; Transcription factor involved in the formation of pseudohyphae and hyphae. It is likely to play a role in the developmental switch between yeast and mycelial forms. May be involved in a signal transduction system, strengthening the possibility of a sexual phase up to now undetected, and similar to that of the yeast mating pathway. | Extent of cell elongation protein 1; Secreted protein involved in biofilm formation. Further cleaved by KEX2 in 8 similar peptides (ECE1- I to ECE1-VIII). | 0.680 |
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