STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMF3Putative divalent metal ion transporter. (514 aa)    
Predicted Functional Partners:
MRS4
Fe(2+) transporter; Belongs to the mitochondrial carrier (TC 2.A.29) family.
      
 0.885
CCC1
Ccc1p.
      
 0.867
FTH1
Fth1p.
   
  
 0.693
AFT2
Iron-regulated transcriptional activator AFT2; Transcription factor involved in iron metabolism, oxidative stress, surface adhesion, hyphal development and virulence. Functions as a negative regulator of MRS4 expression through the CACCC AFT-type sequence in a gene dose-dependent fashion. Acts as a repressor in flocculation, plastic adhesion, and surface hydrophobicity.
      
 0.674
ELF1
Elf1p.
     
 0.628
CEF3
Elongation factor 3; The main role of EF-3 may be to transduce nucleoside triphosphate energy into mechanical energy for translocation during translation. EF-3 stimulates EF-1-alpha-dependent binding of aminoacyl- tRNA to the ribosome.
     
 0.628
CCC2
Cu(2+)-transporting P-type ATPase.
  
 
 0.567
FET3
Ferroxidase; Belongs to the multicopper oxidase family.
  
 
 0.537
FTR1
High-affinity iron permease.
   
  
 0.527
CaO19.6509
Glutaredoxin domain-containing protein.
   
  
 0.511
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.