STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSX11Ceramide glucosyltransferase; Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide. Glucosylceramides play important roles in growth, differentiation and pathogenicity; Belongs to the glycosyltransferase 2 family. (544 aa)    
Predicted Functional Partners:
ISC1
Inositol phosphosphingolipid phospholipase.
   
 
 0.974
DES1
Sphingolipid delta(4)-desaturase; Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides. Required for the formation of the monounsaturated sphingoid base (E)-sphing-4- enine during glucosylceramide (GluCer) biosynthesis. Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.
     
 0.971
SLD1
Delta 8-(E)-sphingolipid desaturase; Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga- 4,8-dienine during glucosylceramide (GluCer) biosynthesis.
      
 0.878
CaO19.6438
Serine C-palmitoyltransferase.
  
 
 0.781
LCB2
Serine C-palmitoyltransferase.
  
 
 0.779
MTS1
Sphingolipid C9-methyltransferase; Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9- methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals, and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. Not necessary for vegetative growt [...]
    
 
 0.696
TRP5
Tryptophan synthase.
  
 
 0.692
TRP3
Bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase.
  
 
 0.681
GCS1
Glutamate--cysteine ligase.
      
 0.673
ILV3
Dihydroxy-acid dehydratase.
  
  
 0.673
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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