node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BCY1 | CYR1 | Q9HEW1 | A0A1D8PR83 | cAMP-dependent protein kinase regulatory subunit. | Adenylate cyclase. | 0.942 |
BCY1 | EFG1 | Q9HEW1 | Q59X67 | cAMP-dependent protein kinase regulatory subunit. | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | 0.562 |
BCY1 | PDE2 | Q9HEW1 | A0A1D8PCV9 | cAMP-dependent protein kinase regulatory subunit. | Phosphodiesterase. | 0.907 |
BCY1 | RAS1 | Q9HEW1 | Q59XU5 | cAMP-dependent protein kinase regulatory subunit. | Ras-like protein 1; Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity). | 0.812 |
BCY1 | RAS2 | Q9HEW1 | Q5ANJ9 | cAMP-dependent protein kinase regulatory subunit. | Ras2p. | 0.775 |
BCY1 | TPK1 | Q9HEW1 | Q5AP71 | cAMP-dependent protein kinase regulatory subunit. | Tpk1p; Belongs to the protein kinase superfamily. | 0.999 |
BCY1 | TPK2 | Q9HEW1 | A0A1D8PHU1 | cAMP-dependent protein kinase regulatory subunit. | cAMP-dependent protein kinase catalytic subunit; Belongs to the protein kinase superfamily. | 0.999 |
CYR1 | BCY1 | A0A1D8PR83 | Q9HEW1 | Adenylate cyclase. | cAMP-dependent protein kinase regulatory subunit. | 0.942 |
CYR1 | EFG1 | A0A1D8PR83 | Q59X67 | Adenylate cyclase. | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | 0.693 |
CYR1 | PDE2 | A0A1D8PR83 | A0A1D8PCV9 | Adenylate cyclase. | Phosphodiesterase. | 0.991 |
CYR1 | RAS1 | A0A1D8PR83 | Q59XU5 | Adenylate cyclase. | Ras-like protein 1; Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity). | 0.998 |
CYR1 | RAS2 | A0A1D8PR83 | Q5ANJ9 | Adenylate cyclase. | Ras2p. | 0.991 |
CYR1 | TPK1 | A0A1D8PR83 | Q5AP71 | Adenylate cyclase. | Tpk1p; Belongs to the protein kinase superfamily. | 0.991 |
CYR1 | TPK2 | A0A1D8PR83 | A0A1D8PHU1 | Adenylate cyclase. | cAMP-dependent protein kinase catalytic subunit; Belongs to the protein kinase superfamily. | 0.992 |
EFG1 | BCY1 | Q59X67 | Q9HEW1 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | cAMP-dependent protein kinase regulatory subunit. | 0.562 |
EFG1 | CYR1 | Q59X67 | A0A1D8PR83 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | Adenylate cyclase. | 0.693 |
EFG1 | EFH1 | Q59X67 | Q59P39 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | Transcriptional regulator EFH1; Transcription factor that regulates filamentous growth through repression of EFG1. Regulates the level of colonizing fungi, favoring commensalism as opposed to candidiasis. | 0.934 |
EFG1 | MKC1 | Q59X67 | Q5AAG6 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | Mitogen-activated protein kinase MKC1; Serine/threonine protein kinase component of the cell integrity pathway, a signal transduction pathway that plays a role in yeast cell morphogenesis and cell growth. Participates in cell wall construction, azole resistance, and host interaction. Required for the signaling for invasive filamentous growth and biofilm formation, and plays a crucial role in virulence. | 0.511 |
EFG1 | PDE2 | Q59X67 | A0A1D8PCV9 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | Phosphodiesterase. | 0.512 |
EFG1 | RAS1 | Q59X67 | Q59XU5 | Enhanced filamentous growth protein 1; Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. Antagonizes the action of WOR1, WOR2 and CZF1, and promotes the white state. In white cells, EFG1 represses WOR1 indirectly through WOR2 to maintain white cell identity. Binds target gene promoters at the EFG1 recognition sequenc [...] | Ras-like protein 1; Required for the regulation of both a MAP kinase signaling pathway and a cAMP signaling pathway. The activation of these pathways contributes to the pathogenicity of the cells through the induction of the morphological transition from the yeast to the polarized filamentous form (By similarity). | 0.866 |