STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLA4Serine/threonine-protein kinase CLA4; Ser/Thr kinase required for wild-type filamentous growth, chlamydospore formation, and virulence in mouse systemic infection. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (976 aa)    
Predicted Functional Partners:
CDC42
Cell division control protein 42 homolog; Involved in hyphal formation, virulence, morphogenesis; Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.
   
 0.998
RGA2
Rga2p.
    
 0.997
BEM1
Phosphatidylinositol-3-phosphate-binding protein.
   
 0.986
STE4
G protein subunit beta.
    
 0.971
STE11
Mitogen-activated protein kinase kinase kinase.
  
 
0.964
CST20
Serine/threonine-protein kinase CST20; MAP4K component of the MAPK pathway required for the mating pheromone response, and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity). Required for hyphal formation and virulence; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  
0.921
STE18
Ste18p.
     
 0.914
RAC1
Rho family GTPase.
   
 0.882
STE50
Ste50p.
    
 
 0.797
SHO1
High osmolarity signaling protein SHO1; Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Mediates resistance to oxidative stress. Controls the activation of the CEK1 MAP kinase. Influences the molecular weight and polymer distribution of cell wall mannan. Involved in invasive filamentation into semi-solid medium and plays a role in morphological dimorphic transition which is a differentiation program characteristic of C.albicans and which is known to play a major role in pathogenesis. Belongs to the SHO1 [...]
   
 0.777
Your Current Organism:
Candida albicans
NCBI taxonomy Id: 237561
Other names: C. albicans SC5314, Candida albicans SC5314
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