node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BUR2 | CRK1 | Q5AG95 | Q9Y7W4 | Bur2p; Belongs to the cyclin family. | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | 0.999 |
BUR2 | CaO19.1041 | Q5AG95 | A0A1D8PD68 | Bur2p; Belongs to the cyclin family. | CYCLIN domain-containing protein; Belongs to the cyclin family. | 0.774 |
BUR2 | CaO19.4542 | Q5AG95 | Q59T89 | Bur2p; Belongs to the cyclin family. | TFIIH complex kinase subunit; Belongs to the cyclin family. | 0.850 |
BUR2 | CaO19.5350 | Q5AG95 | Q5A5P9 | Bur2p; Belongs to the cyclin family. | CID domain-containing protein. | 0.813 |
BUR2 | CaO19.6742 | Q5AG95 | Q5ADU9 | Bur2p; Belongs to the cyclin family. | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. | 0.783 |
BUR2 | KIN28 | Q5AG95 | Q5AAS1 | Bur2p; Belongs to the cyclin family. | TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. | 0.844 |
BUR2 | MED1 | Q5AG95 | Q5AHH0 | Bur2p; Belongs to the cyclin family. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.758 |
BUR2 | RPO21 | Q5AG95 | A0A1D8PUA6 | Bur2p; Belongs to the cyclin family. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.909 |
BUR2 | SPT4 | Q5AG95 | Q5AK73 | Bur2p; Belongs to the cyclin family. | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.887 |
BUR2 | SPT5 | Q5AG95 | Q5ALX3 | Bur2p; Belongs to the cyclin family. | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.932 |
CRK1 | BUR2 | Q9Y7W4 | Q5AG95 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | Bur2p; Belongs to the cyclin family. | 0.999 |
CRK1 | CaO19.1041 | Q9Y7W4 | A0A1D8PD68 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | CYCLIN domain-containing protein; Belongs to the cyclin family. | 0.927 |
CRK1 | CaO19.4542 | Q9Y7W4 | Q59T89 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | TFIIH complex kinase subunit; Belongs to the cyclin family. | 0.868 |
CRK1 | CaO19.5350 | Q9Y7W4 | Q5A5P9 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | CID domain-containing protein. | 0.797 |
CRK1 | CaO19.6742 | Q9Y7W4 | Q5ADU9 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. | 0.765 |
CRK1 | KIN28 | Q9Y7W4 | Q5AAS1 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | TFIIH complex serine/threonine-protein kinase subunit; Belongs to the protein kinase superfamily. | 0.767 |
CRK1 | MED1 | Q9Y7W4 | Q5AHH0 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.834 |
CRK1 | RPO21 | Q9Y7W4 | A0A1D8PUA6 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.957 |
CRK1 | SPT4 | Q9Y7W4 | Q5AK73 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.843 |
CRK1 | SPT5 | Q9Y7W4 | Q5ALX3 | Serine/threonine-protein kinase BUR1; Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). Required for pseudohyphal growth and virulence in mice. | Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). | 0.974 |