Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SFB00377.1Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (461 aa)    
Predicted Functional Partners:
SFB00389.1
Dihydrolipoamide dehydrogenase.
 0.999
SFA72167.1
Dihydrolipoamide dehydrogenase.
 0.997
SFB18147.1
Dihydrolipoamide dehydrogenase.
 0.997
SFB00365.1
Pyruvate dehydrogenase E1 component beta subunit.
 0.996
SFB18116.1
Pyruvate dehydrogenase E1 component beta subunit.
 0.993
odhA
2-oxoglutarate dehydrogenase E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
 0.992
SFB00353.1
Pyruvate dehydrogenase E1 component alpha subunit.
 0.986
SFA72201.1
2-oxoisovalerate dehydrogenase E1 component beta subunit.
 0.983
pdhA
Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 
 0.973
SFA72183.1
2-oxoisovalerate dehydrogenase E1 component alpha subunit.
 
 0.967
Your Current Organism:
Lentibacillus halodurans
NCBI taxonomy Id: 237679
Other names: Bacillaceae bacterium 8-1, CGMCC 1.3702, DSM 18342, L. halodurans, Lentibacillus halodurans Yuan et al. 2007, strain 8-1
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