node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ27704.1 | EAQ27706.1 | NAP1_08927 | NAP1_08937 | Peptidase, M50 family protein; COG1994 Zn-dependent proteases. | Hypothetical protein; COG2978 Putative p-aminobenzoyl-glutamate transporter. | 0.588 |
EAQ27704.1 | tdk | NAP1_08927 | NAP1_08932 | Peptidase, M50 family protein; COG1994 Zn-dependent proteases. | COG1435 Thymidine kinase. | 0.747 |
EAQ27706.1 | EAQ27704.1 | NAP1_08937 | NAP1_08927 | Hypothetical protein; COG2978 Putative p-aminobenzoyl-glutamate transporter. | Peptidase, M50 family protein; COG1994 Zn-dependent proteases. | 0.588 |
EAQ27706.1 | tdk | NAP1_08937 | NAP1_08932 | Hypothetical protein; COG2978 Putative p-aminobenzoyl-glutamate transporter. | COG1435 Thymidine kinase. | 0.627 |
EAQ28181.1 | tdk | NAP1_11318 | NAP1_08932 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | COG1435 Thymidine kinase. | 0.973 |
EAQ28422.1 | dut | NAP1_12523 | NAP1_11088 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.638 |
EAQ28422.1 | tdk | NAP1_12523 | NAP1_08932 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG1435 Thymidine kinase. | 0.638 |
EAQ28422.1 | thyA | NAP1_12523 | NAP1_04380 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.996 |
EAQ28422.1 | tmk | NAP1_12523 | NAP1_05485 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.641 |
dut | EAQ28422.1 | NAP1_11088 | NAP1_12523 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.638 |
dut | tdk | NAP1_11088 | NAP1_08932 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | COG1435 Thymidine kinase. | 0.980 |
dut | thyA | NAP1_11088 | NAP1_04380 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.986 |
dut | tmk | NAP1_11088 | NAP1_05485 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.952 |
prfA | pyrG | NAP1_11868 | NAP1_05725 | Protein chain release factor A; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.652 |
prfA | tdk | NAP1_11868 | NAP1_08932 | Protein chain release factor A; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | COG1435 Thymidine kinase. | 0.844 |
pyrG | prfA | NAP1_05725 | NAP1_11868 | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | Protein chain release factor A; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.652 |
pyrG | tdk | NAP1_05725 | NAP1_08932 | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | COG1435 Thymidine kinase. | 0.599 |
tadA | tdk | NAP1_13348 | NAP1_08932 | Cytidine/deoxycytidylate deaminase, zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | COG1435 Thymidine kinase. | 0.652 |
tadA | thyA | NAP1_13348 | NAP1_04380 | Cytidine/deoxycytidylate deaminase, zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.614 |
tadA | tmk | NAP1_13348 | NAP1_05485 | Cytidine/deoxycytidylate deaminase, zinc-binding region; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.585 |