node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAQ28745.1 | EAQ28923.1 | NAP1_14138 | NAP1_15028 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG0287 Prephenate dehydrogenase. | 0.792 |
EAQ28745.1 | EAQ29631.1 | NAP1_14138 | NAP1_02625 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG1605 Chorismate mutase. | 0.934 |
EAQ28745.1 | EAQ30258.1 | NAP1_14138 | NAP1_05760 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | COG0512 Anthranilate/para-aminobenzoate synthases component II. | 0.999 |
EAQ28745.1 | aroA | NAP1_14138 | NAP1_06740 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.619 |
EAQ28745.1 | aroB | NAP1_14138 | NAP1_04105 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.705 |
EAQ28745.1 | aroC | NAP1_14138 | NAP1_10973 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.966 |
EAQ28745.1 | aroE | NAP1_14138 | NAP1_13038 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.819 |
EAQ28745.1 | aroK | NAP1_14138 | NAP1_04110 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.786 |
EAQ28745.1 | trpA | NAP1_14138 | NAP1_06860 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.969 |
EAQ28745.1 | trpE | NAP1_14138 | NAP1_05745 | COG0147 Anthranilate/para-aminobenzoate synthases component I. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.906 |
EAQ28923.1 | EAQ28745.1 | NAP1_15028 | NAP1_14138 | COG0287 Prephenate dehydrogenase. | COG0147 Anthranilate/para-aminobenzoate synthases component I. | 0.792 |
EAQ28923.1 | EAQ29631.1 | NAP1_15028 | NAP1_02625 | COG0287 Prephenate dehydrogenase. | COG1605 Chorismate mutase. | 0.946 |
EAQ28923.1 | EAQ30258.1 | NAP1_15028 | NAP1_05760 | COG0287 Prephenate dehydrogenase. | COG0512 Anthranilate/para-aminobenzoate synthases component II. | 0.641 |
EAQ28923.1 | aroA | NAP1_15028 | NAP1_06740 | COG0287 Prephenate dehydrogenase. | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.989 |
EAQ28923.1 | aroB | NAP1_15028 | NAP1_04105 | COG0287 Prephenate dehydrogenase. | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.741 |
EAQ28923.1 | aroC | NAP1_15028 | NAP1_10973 | COG0287 Prephenate dehydrogenase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.913 |
EAQ28923.1 | aroE | NAP1_15028 | NAP1_13038 | COG0287 Prephenate dehydrogenase. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.419 |
EAQ28923.1 | aroK | NAP1_15028 | NAP1_04110 | COG0287 Prephenate dehydrogenase. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.668 |
EAQ28923.1 | trpA | NAP1_15028 | NAP1_06860 | COG0287 Prephenate dehydrogenase. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.666 |
EAQ28923.1 | trpE | NAP1_15028 | NAP1_05745 | COG0287 Prephenate dehydrogenase. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.545 |