STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACP_03282-oxoacid:ferredoxin/flavodoxin oxidoreductase gamma subunit family protein; Identified by match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR03710. (618 aa)    
Predicted Functional Partners:
ACP_0329
Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; Identified by similarity to GB:BAA10899.1; match to protein family HMM PF02775.
 
 0.999
ACP_2686
Pyruvate ferrodoxin oxidoreductase; Identified by similarity to GB:CAA70873.1; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM TIGR02176.
  
 0.999
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.949
sucC
succinyl-CoA synthase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.948
acsA
acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.947
ACP_0481
Phosphate acetyltransferase; Identified by similarity to GB:AAA75486.1; match to protein family HMM PF01515.
    
 0.944
pyk
Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family.
   
 0.944
ACP_2736
Malate dehydrogenase (oxaloacetate-decarboxylating); Identified by similarity to SP:P26616; match to protein family HMM PF00390; match to protein family HMM PF03949.
  
 
 0.943
ACP_1662
HMGL domain protein; Identified by match to protein family HMM PF00682.
  
 
 0.938
leuA
2-isopropylmalate synthase; Identified by similarity to SP:Q8RL85; match to protein family HMM PF00682; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.938
Your Current Organism:
Acidobacterium capsulatum
NCBI taxonomy Id: 240015
Other names: A. capsulatum ATCC 51196, Acidobacterium capsulatum ATCC 51196, Acidobacterium capsulatum str. ATCC 51196, Acidobacterium capsulatum strain ATCC 51196
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.