node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP_0713 | hemA | ACP_0713 | ACP_0712 | Identified by match to protein family HMM PF01578. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.870 |
ACP_0713 | hemC | ACP_0713 | ACP_0711 | Identified by match to protein family HMM PF01578. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.800 |
ACP_0713 | hemD | ACP_0713 | ACP_0710 | Identified by match to protein family HMM PF01578. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.685 |
ACP_3018 | cobA | ACP_3018 | ACP_3338 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.999 |
ACP_3018 | hemA | ACP_3018 | ACP_0712 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.543 |
ACP_3018 | hemB | ACP_3018 | ACP_2188 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.710 |
ACP_3018 | hemC | ACP_3018 | ACP_0711 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.887 |
ACP_3018 | hemD | ACP_3018 | ACP_0710 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.647 |
ACP_3018 | hemL | ACP_3018 | ACP_2074 | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00713. | 0.744 |
cobA | ACP_3018 | ACP_3338 | ACP_3018 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | 0.999 |
cobA | hemA | ACP_3338 | ACP_0712 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.763 |
cobA | hemB | ACP_3338 | ACP_2188 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.884 |
cobA | hemC | ACP_3338 | ACP_0711 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.991 |
cobA | hemD | ACP_3338 | ACP_0710 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.997 |
cobA | hemE | ACP_3338 | ACP_2432 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.936 |
cobA | hemL | ACP_3338 | ACP_2074 | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Glutamate-1-semialdehyde-2,1-aminomutase; Identified by match to protein family HMM PF00202; match to protein family HMM TIGR00713. | 0.643 |
hemA | ACP_0713 | ACP_0712 | ACP_0713 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Identified by match to protein family HMM PF01578. | 0.870 |
hemA | ACP_3018 | ACP_0712 | ACP_3018 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Siroheme synthase, N-terminal domain protein; Identified by match to protein family HMM TIGR01470. | 0.543 |
hemA | cobA | ACP_0712 | ACP_3338 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | uroporphyrinogen-III C-methyltransferase; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.763 |
hemA | hemB | ACP_0712 | ACP_2188 | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.856 |