node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP_0606 | ACP_3455 | ACP_0606 | ACP_3455 | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | 0.984 |
ACP_0606 | mqnA | ACP_0606 | ACP_3417 | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.832 |
ACP_0606 | mqnC | ACP_0606 | ACP_1642 | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.812 |
ACP_0606 | mqnD | ACP_0606 | ACP_0136 | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. | 0.809 |
ACP_0606 | mqnE | ACP_0606 | ACP_0913 | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | Conserved hypothetical protein TIGR00423; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.815 |
ACP_0606 | ubiX | ACP_0606 | ACP_2462 | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.982 |
ACP_2460 | ada | ACP_2460 | ACP_2459 | Hypothetical protein; Identified by glimmer; putative. | ADA regulatory protein; Identified by similarity to SP:P06134; match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589. | 0.547 |
ACP_2460 | purB | ACP_2460 | ACP_2461 | Hypothetical protein; Identified by glimmer; putative. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.572 |
ACP_2460 | ubiX | ACP_2460 | ACP_2462 | Hypothetical protein; Identified by glimmer; putative. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.572 |
ACP_3455 | ACP_0606 | ACP_3455 | ACP_0606 | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | 0.984 |
ACP_3455 | mqnA | ACP_3455 | ACP_3417 | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.730 |
ACP_3455 | mqnC | ACP_3455 | ACP_1642 | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | Radical SAM domain protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). | 0.625 |
ACP_3455 | mqnD | ACP_3455 | ACP_0136 | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | Conserved hypothetical protein; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. | 0.684 |
ACP_3455 | mqnE | ACP_3455 | ACP_0913 | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | Conserved hypothetical protein TIGR00423; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. | 0.657 |
ACP_3455 | ubiX | ACP_3455 | ACP_2462 | Decarboxylase, UbiD family; Identified by match to protein family HMM PF01977; match to protein family HMM TIGR00148; match to protein family HMM TIGR03701; Belongs to the UbiD family. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.994 |
acsA | ubiX | ACP_2811 | ACP_2462 | acetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.626 |
ada | ACP_2460 | ACP_2459 | ACP_2460 | ADA regulatory protein; Identified by similarity to SP:P06134; match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589. | Hypothetical protein; Identified by glimmer; putative. | 0.547 |
ada | purB | ACP_2459 | ACP_2461 | ADA regulatory protein; Identified by similarity to SP:P06134; match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589. | Adenylosuccinate lyase; Identified by match to protein family HMM PF00206; match to protein family HMM TIGR00928; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.487 |
ada | ubiX | ACP_2459 | ACP_2462 | ADA regulatory protein; Identified by similarity to SP:P06134; match to protein family HMM PF00165; match to protein family HMM PF01035; match to protein family HMM PF02805; match to protein family HMM PF02870; match to protein family HMM TIGR00589. | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. | 0.417 |
mqnA | ACP_0606 | ACP_3417 | ACP_0606 | Conserved hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). | Putative 4-hydroxybenzoate polyprenyltransferase; Identified by match to protein family HMM PF01040; match to protein family HMM TIGR01475; Belongs to the UbiA prenyltransferase family. | 0.832 |