node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACP_0819 | ACP_2694 | ACP_0819 | ACP_2694 | Identified by match to protein family HMM PF06778. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.923 |
ACP_0819 | hemG1 | ACP_0819 | ACP_2434 | Identified by match to protein family HMM PF06778. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.574 |
ACP_0819 | hemG2 | ACP_0819 | ACP_2693 | Identified by match to protein family HMM PF06778. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.527 |
ACP_0819 | hemH | ACP_0819 | ACP_2433 | Identified by match to protein family HMM PF06778. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.967 |
ACP_1714 | hemC | ACP_1714 | ACP_0711 | Putative magnesium chelatase, ChlI subunit. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.498 |
ACP_1714 | hemG1 | ACP_1714 | ACP_2434 | Putative magnesium chelatase, ChlI subunit. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.915 |
ACP_1714 | hemG2 | ACP_1714 | ACP_2693 | Putative magnesium chelatase, ChlI subunit. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.915 |
ACP_1714 | hemH | ACP_1714 | ACP_2433 | Putative magnesium chelatase, ChlI subunit. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.918 |
ACP_2694 | ACP_0819 | ACP_2694 | ACP_0819 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Identified by match to protein family HMM PF06778. | 0.923 |
ACP_2694 | hemB | ACP_2694 | ACP_2188 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | 0.608 |
ACP_2694 | hemC | ACP_2694 | ACP_0711 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.624 |
ACP_2694 | hemD | ACP_2694 | ACP_0710 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.628 |
ACP_2694 | hemG1 | ACP_2694 | ACP_2434 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.638 |
ACP_2694 | hemG2 | ACP_2694 | ACP_2693 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.914 |
ACP_2694 | hemH | ACP_2694 | ACP_2433 | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.959 |
ACP_3491 | hemC | ACP_3491 | ACP_0711 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.484 |
ACP_3491 | hemE | ACP_3491 | ACP_2432 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.946 |
ACP_3491 | hemG1 | ACP_3491 | ACP_2434 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.928 |
ACP_3491 | hemG2 | ACP_3491 | ACP_2693 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.927 |
hemB | ACP_2694 | ACP_2188 | ACP_2694 | Porphobilinogen synthase; Identified by match to protein family HMM PF00490; Belongs to the ALAD family. | Radical SAM domain protein; Identified by match to protein family HMM PF04055. | 0.608 |