| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ava_0100 | Ava_0101 | Ava_0100 | Ava_0101 | Protein of unknown function DUF820. | C-5 cytosine-specific DNA methylase. | 0.466 |
| Ava_0101 | Ava_0100 | Ava_0101 | Ava_0100 | C-5 cytosine-specific DNA methylase. | Protein of unknown function DUF820. | 0.466 |
| Ava_0101 | Ava_0731 | Ava_0101 | Ava_0731 | C-5 cytosine-specific DNA methylase. | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.925 |
| Ava_0101 | Ava_2963 | Ava_0101 | Ava_2963 | C-5 cytosine-specific DNA methylase. | ABC transporter-like protein. | 0.434 |
| Ava_0101 | Ava_4899 | Ava_0101 | Ava_4899 | C-5 cytosine-specific DNA methylase. | Methionine adenosyltransferase; Belongs to the AdoMet synthase family. | 0.919 |
| Ava_0101 | ahcY | Ava_0101 | Ava_3963 | C-5 cytosine-specific DNA methylase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.907 |
| Ava_0101 | metK | Ava_0101 | Ava_0780 | C-5 cytosine-specific DNA methylase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.919 |
| Ava_0101 | pyrB | Ava_0101 | Ava_1174 | C-5 cytosine-specific DNA methylase. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.646 |
| Ava_0101 | pyrE | Ava_0101 | Ava_0957 | C-5 cytosine-specific DNA methylase. | Orotate phosphoribosyl transferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.647 |
| Ava_0101 | pyrE-2 | Ava_0101 | Ava_2358 | C-5 cytosine-specific DNA methylase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.647 |
| Ava_0101 | pyrF | Ava_0101 | Ava_0924 | C-5 cytosine-specific DNA methylase. | Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.605 |
| Ava_0731 | Ava_0101 | Ava_0731 | Ava_0101 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | C-5 cytosine-specific DNA methylase. | 0.925 |
| Ava_0731 | Ava_4899 | Ava_0731 | Ava_4899 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Methionine adenosyltransferase; Belongs to the AdoMet synthase family. | 0.919 |
| Ava_0731 | ahcY | Ava_0731 | Ava_3963 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.907 |
| Ava_0731 | metK | Ava_0731 | Ava_0780 | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.919 |
| Ava_2963 | Ava_0101 | Ava_2963 | Ava_0101 | ABC transporter-like protein. | C-5 cytosine-specific DNA methylase. | 0.434 |
| Ava_4899 | Ava_0101 | Ava_4899 | Ava_0101 | Methionine adenosyltransferase; Belongs to the AdoMet synthase family. | C-5 cytosine-specific DNA methylase. | 0.919 |
| Ava_4899 | Ava_0731 | Ava_4899 | Ava_0731 | Methionine adenosyltransferase; Belongs to the AdoMet synthase family. | C-5 cytosine-specific DNA methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.919 |
| Ava_4899 | ahcY | Ava_4899 | Ava_3963 | Methionine adenosyltransferase; Belongs to the AdoMet synthase family. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.741 |
| Ava_4899 | metK | Ava_4899 | Ava_0780 | Methionine adenosyltransferase; Belongs to the AdoMet synthase family. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.904 |