| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ava_0198 | Ava_1457 | Ava_0198 | Ava_1457 | Multi-sensor hybrid histidine kinase. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.726 |
| Ava_0198 | Ava_2118 | Ava_0198 | Ava_2118 | Multi-sensor hybrid histidine kinase. | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | 0.519 |
| Ava_0198 | Ava_4428 | Ava_0198 | Ava_4428 | Multi-sensor hybrid histidine kinase. | Fmu, rRNA SAM-dependent methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.486 |
| Ava_0198 | pyrE | Ava_0198 | Ava_0957 | Multi-sensor hybrid histidine kinase. | Orotate phosphoribosyl transferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.671 |
| Ava_0198 | ribBA | Ava_0198 | Ava_3515 | Multi-sensor hybrid histidine kinase. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.707 |
| Ava_0198 | ribH | Ava_0198 | Ava_1704 | Multi-sensor hybrid histidine kinase. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.603 |
| Ava_0949 | Ava_1457 | Ava_0949 | Ava_1457 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.748 |
| Ava_0949 | ribBA | Ava_0949 | Ava_3515 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.696 |
| Ava_0949 | ribH | Ava_0949 | Ava_1704 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.424 |
| Ava_1416 | Ava_1457 | Ava_1416 | Ava_1457 | Lumazine-binding protein. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| Ava_1416 | Ava_2118 | Ava_1416 | Ava_2118 | Lumazine-binding protein. | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | 0.953 |
| Ava_1416 | ribBA | Ava_1416 | Ava_3515 | Lumazine-binding protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
| Ava_1416 | ribH | Ava_1416 | Ava_1704 | Lumazine-binding protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| Ava_1457 | Ava_0198 | Ava_1457 | Ava_0198 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Multi-sensor hybrid histidine kinase. | 0.726 |
| Ava_1457 | Ava_0949 | Ava_1457 | Ava_0949 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 0.748 |
| Ava_1457 | Ava_1416 | Ava_1457 | Ava_1416 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Lumazine-binding protein. | 0.999 |
| Ava_1457 | Ava_2118 | Ava_1457 | Ava_2118 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | 0.707 |
| Ava_1457 | Ava_2289 | Ava_1457 | Ava_2289 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Conserved hypothetical protein. | 0.933 |
| Ava_1457 | Ava_4428 | Ava_1457 | Ava_4428 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Fmu, rRNA SAM-dependent methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.749 |
| Ava_1457 | eno | Ava_1457 | Ava_3517 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. | 0.945 |
