| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ava_1214 | Ava_2118 | Ava_1214 | Ava_2118 | NADPH-dependent FMN reductase. | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | 0.907 |
| Ava_1416 | Ava_1457 | Ava_1416 | Ava_1457 | Lumazine-binding protein. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.999 |
| Ava_1416 | Ava_2118 | Ava_1416 | Ava_2118 | Lumazine-binding protein. | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | 0.953 |
| Ava_1416 | panC/cmk | Ava_1416 | Ava_0964 | Lumazine-binding protein. | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.401 |
| Ava_1416 | ribBA | Ava_1416 | Ava_3515 | Lumazine-binding protein. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
| Ava_1416 | ribH | Ava_1416 | Ava_1704 | Lumazine-binding protein. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.999 |
| Ava_1457 | Ava_1416 | Ava_1457 | Ava_1416 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Lumazine-binding protein. | 0.999 |
| Ava_1457 | Ava_2118 | Ava_1457 | Ava_2118 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | 0.707 |
| Ava_1457 | coaD | Ava_1457 | Ava_1966 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.600 |
| Ava_1457 | gmk | Ava_1457 | Ava_1475 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.511 |
| Ava_1457 | mnmA | Ava_1457 | Ava_4065 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.497 |
| Ava_1457 | panC/cmk | Ava_1457 | Ava_0964 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.698 |
| Ava_1457 | ribBA | Ava_1457 | Ava_3515 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.999 |
| Ava_1457 | ribH | Ava_1457 | Ava_1704 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.988 |
| Ava_2118 | Ava_1214 | Ava_2118 | Ava_1214 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | NADPH-dependent FMN reductase. | 0.907 |
| Ava_2118 | Ava_1416 | Ava_2118 | Ava_1416 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | Lumazine-binding protein. | 0.953 |
| Ava_2118 | Ava_1457 | Ava_2118 | Ava_1457 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.707 |
| Ava_2118 | coaD | Ava_2118 | Ava_1966 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.750 |
| Ava_2118 | gmk | Ava_2118 | Ava_1475 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.722 |
| Ava_2118 | mnmA | Ava_2118 | Ava_4065 | FMN adenylyltransferase / riboflavin kinase; Belongs to the ribF family. | tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. | 0.634 |
