| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ava_0949 | Ava_1457 | Ava_0949 | Ava_1457 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.748 |
| Ava_0949 | Ava_3225 | Ava_0949 | Ava_3225 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.997 |
| Ava_0949 | Ava_3289 | Ava_0949 | Ava_3289 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.999 |
| Ava_0949 | Ava_3683 | Ava_0949 | Ava_3683 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.729 |
| Ava_0949 | folE-2 | Ava_0949 | Ava_2537 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | GTP cyclohydrolase I. | 0.957 |
| Ava_0949 | panC/cmk | Ava_0949 | Ava_0964 | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.591 |
| Ava_1457 | Ava_0949 | Ava_1457 | Ava_0949 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 0.748 |
| Ava_1457 | Ava_3225 | Ava_1457 | Ava_3225 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.668 |
| Ava_1457 | Ava_3289 | Ava_1457 | Ava_3289 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.554 |
| Ava_1457 | Ava_3683 | Ava_1457 | Ava_3683 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.636 |
| Ava_1457 | Ava_4321 | Ava_1457 | Ava_4321 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Bifunctional deaminase-reductase-like protein. | 0.563 |
| Ava_1457 | folE-2 | Ava_1457 | Ava_2537 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GTP cyclohydrolase I. | 0.603 |
| Ava_1457 | guaA | Ava_1457 | Ava_1054 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.653 |
| Ava_1457 | panC/cmk | Ava_1457 | Ava_0964 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Cytidylate kinase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily. | 0.698 |
| Ava_1457 | serS | Ava_1457 | Ava_1724 | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). | 0.479 |
| Ava_3225 | Ava_0949 | Ava_3225 | Ava_0949 | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK. | 0.997 |
| Ava_3225 | Ava_1457 | Ava_3225 | Ava_1457 | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.668 |
| Ava_3225 | Ava_3289 | Ava_3225 | Ava_3289 | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.994 |
| Ava_3225 | Ava_3683 | Ava_3225 | Ava_3683 | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.669 |
| Ava_3225 | folE-2 | Ava_3225 | Ava_2537 | Dihydroneopterin aldolase family; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.951 |
