CDQ17983.1 protein (Halobacillus dabanensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CDQ17983.1

Type IV pilin biogenesis protein. (350 aa)

Predicted Functional Partners:

gspE_2

0.994

gspE_1

0.977

comGC

0.975

CDQ17987.1

0.954

comC

0.919

CDQ18060.1

0.866

comEA

0.805

CDQ17985.1

0.804

mfd_1

0.756

ssb

0.748

Your Current Organism:

Halobacillus dabanensis

NCBI taxonomy Id: 240302
Other names: CGMCC 1.3704, H. dabanensis, Halobacillus dabanensis Liu et al. 2005, Halobacillus sp. D-8, JCM 12772, strain D-8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDQ17983.1	CDQ17985.1	BN982_00223	BN982_00225	Type IV pilin biogenesis protein.	Hypothetical protein.	0.804
CDQ17983.1	CDQ17987.1	BN982_00223	BN982_00227	Type IV pilin biogenesis protein.	Hypothetical protein.	0.954
CDQ17983.1	CDQ18060.1	BN982_00223	BN982_00306	Type IV pilin biogenesis protein.	ComEC family competence protein.	0.866
CDQ17983.1	comC	BN982_00223	BN982_00435	Type IV pilin biogenesis protein.	Late competence protein ComC.	0.919
CDQ17983.1	comEA	BN982_00223	BN982_00308	Type IV pilin biogenesis protein.	ComE operon protein 1.	0.805
CDQ17983.1	comGC	BN982_00223	BN982_00224	Type IV pilin biogenesis protein.	ComG operon protein 3 precursor.	0.975
CDQ17983.1	gspE_1	BN982_00223	BN982_00164	Type IV pilin biogenesis protein.	Type II traffic warden ATPase.	0.977
CDQ17983.1	gspE_2	BN982_00223	BN982_00222	Type IV pilin biogenesis protein.	Type II traffic warden ATPase.	0.994
CDQ17983.1	mfd_1	BN982_00223	BN982_01488	Type IV pilin biogenesis protein.	Transcription-repair-coupling factor.	0.756
CDQ17983.1	ssb	BN982_00223	BN982_00689	Type IV pilin biogenesis protein.	Helix-destabilizing protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.748
CDQ17985.1	CDQ17983.1	BN982_00225	BN982_00223	Hypothetical protein.	Type IV pilin biogenesis protein.	0.804
CDQ17985.1	CDQ17987.1	BN982_00225	BN982_00227	Hypothetical protein.	Hypothetical protein.	0.800
CDQ17985.1	comGC	BN982_00225	BN982_00224	Hypothetical protein.	ComG operon protein 3 precursor.	0.800
CDQ17985.1	gspE_2	BN982_00225	BN982_00222	Hypothetical protein.	Type II traffic warden ATPase.	0.774
CDQ17987.1	CDQ17983.1	BN982_00227	BN982_00223	Hypothetical protein.	Type IV pilin biogenesis protein.	0.954
CDQ17987.1	CDQ17985.1	BN982_00227	BN982_00225	Hypothetical protein.	Hypothetical protein.	0.800
CDQ17987.1	CDQ18060.1	BN982_00227	BN982_00306	Hypothetical protein.	ComEC family competence protein.	0.726
CDQ17987.1	comC	BN982_00227	BN982_00435	Hypothetical protein.	Late competence protein ComC.	0.626
CDQ17987.1	comEA	BN982_00227	BN982_00308	Hypothetical protein.	ComE operon protein 1.	0.598
CDQ17987.1	comGC	BN982_00227	BN982_00224	Hypothetical protein.	ComG operon protein 3 precursor.	0.965

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.873

expected number of edges:

12

PPI enrichment p-value:

6.95e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006281

DNA repair

7 of 49

1.67

2.66

6.47e-08

GO:0006284

Base-excision repair

3 of 8

2.09

1.73

0.00042

GO:0006259

DNA metabolic process

8 of 141

1.27

1.67

4.10e-07

GO:0051716

Cellular response to stimulus

8 of 223

1.07

1.17

8.18e-06

GO:0043170

Macromolecule metabolic process

9 of 703

0.62

0.48

0.0018

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004527

Exonuclease activity

5 of 23

1.85

2.46

2.79e-06

GO:0140097

Catalytic activity, acting on DNA

8 of 83

1.5

2.4

1.41e-08

GO:0008853

Exodeoxyribonuclease III activity

3 of 4

2.39

2.1

0.00011

GO:0019104

DNA N-glycosylase activity

3 of 11

1.95

1.64

0.00050

GO:0004519

Endonuclease activity

3 of 26

1.57

1.14

0.0032

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:684

AP endonuclease 1, and DNA glycosylase

5 of 7

2.37

3.66

6.00e-08

CL:578

Catalytic activity, acting on DNA, and DNA replication

7 of 65

1.54

2.34

1.24e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

woc03410

Base excision repair

7 of 15

2.18

5.1

4.09e-12

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0326

Glycosidase

2 of 6

2.03

0.85

0.0258

KW-0239

DNA-directed DNA polymerase

2 of 7

1.97

0.84

0.0258

KW-0227

DNA damage

3 of 29

1.53

0.8

0.0221

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR037493

Exodeoxyribonuclease III-like

3 of 3

2.51

1.73

0.00064

IPR023170

Helix-hairpin-helix, base-excision DNA repair, C-terminal

3 of 3

2.51

1.73

0.00064

IPR004808

AP endonuclease 1

3 of 3

2.51

1.73

0.00064

IPR003265

HhH-GPD domain

3 of 3

2.51

1.73

0.00064

IPR011257

DNA glycosylase

3 of 4

2.39

1.71

0.00064

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00525

Iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3)

2 of 2

2.51

1.22

0.0057

SM00278

Helix-hairpin-helix DNA-binding motif class 1

2 of 6

2.03

0.99

0.0133

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