kinA_1 protein (Halobacillus dabanensis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

kinA_1

Sporulation kinase A. (319 aa)

Predicted Functional Partners:

gmr_1

0.999

cheV

0.993

gmr_2

0.990

pfyP_3

0.956

ykuI

0.945

liaS_2

0.939

ribBA

0.936

pfyP_1

0.933

pfyP_2

0.928

cheB

0.922

Your Current Organism:

Halobacillus dabanensis

NCBI taxonomy Id: 240302
Other names: CGMCC 1.3704, H. dabanensis, Halobacillus dabanensis Liu et al. 2005, Halobacillus sp. D-8, JCM 12772, strain D-8

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cheB	cheV	BN982_02026	BN982_02244	Chemotaxis response regulator protein-glutamate methylesterase.	Chemotaxis protein CheV.	0.999
cheB	gmr_1	BN982_02026	BN982_00925	Chemotaxis response regulator protein-glutamate methylesterase.	Cyclic di-GMP phosphodiesterase Gmr.	0.898
cheB	gmr_2	BN982_02026	BN982_02912	Chemotaxis response regulator protein-glutamate methylesterase.	Cyclic di-GMP phosphodiesterase Gmr.	0.891
cheB	kinA_1	BN982_02026	BN982_00924	Chemotaxis response regulator protein-glutamate methylesterase.	Sporulation kinase A.	0.922
cheB	liaS_2	BN982_02026	BN982_02625	Chemotaxis response regulator protein-glutamate methylesterase.	Sensor histidine kinase LiaS.	0.843
cheB	pfyP_1	BN982_02026	BN982_03089	Chemotaxis response regulator protein-glutamate methylesterase.	Hypothetical protein; Phototropin homolog.	0.812
cheB	pfyP_2	BN982_02026	BN982_03990	Chemotaxis response regulator protein-glutamate methylesterase.	Hypothetical protein; Phototropin homolog.	0.767
cheB	pfyP_3	BN982_02026	BN982_03991	Chemotaxis response regulator protein-glutamate methylesterase.	Hypothetical protein; Phototropin homolog.	0.796
cheV	cheB	BN982_02244	BN982_02026	Chemotaxis protein CheV.	Chemotaxis response regulator protein-glutamate methylesterase.	0.999
cheV	gmr_1	BN982_02244	BN982_00925	Chemotaxis protein CheV.	Cyclic di-GMP phosphodiesterase Gmr.	0.996
cheV	gmr_2	BN982_02244	BN982_02912	Chemotaxis protein CheV.	Cyclic di-GMP phosphodiesterase Gmr.	0.984
cheV	kinA_1	BN982_02244	BN982_00924	Chemotaxis protein CheV.	Sporulation kinase A.	0.993
cheV	liaS_2	BN982_02244	BN982_02625	Chemotaxis protein CheV.	Sensor histidine kinase LiaS.	0.961
cheV	pfyP_1	BN982_02244	BN982_03089	Chemotaxis protein CheV.	Hypothetical protein; Phototropin homolog.	0.993
cheV	pfyP_2	BN982_02244	BN982_03990	Chemotaxis protein CheV.	Hypothetical protein; Phototropin homolog.	0.992
cheV	pfyP_3	BN982_02244	BN982_03991	Chemotaxis protein CheV.	Hypothetical protein; Phototropin homolog.	0.992
cheV	ribBA	BN982_02244	BN982_01039	Chemotaxis protein CheV.	Riboflavin biosynthesis protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.	0.901
cheV	ykuI	BN982_02244	BN982_01687	Chemotaxis protein CheV.	Putative EAL-domain containing protein YkuI.	0.938
gmr_1	cheB	BN982_00925	BN982_02026	Cyclic di-GMP phosphodiesterase Gmr.	Chemotaxis response regulator protein-glutamate methylesterase.	0.898
gmr_1	cheV	BN982_00925	BN982_02244	Cyclic di-GMP phosphodiesterase Gmr.	Chemotaxis protein CheV.	0.996

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

28

PPI enrichment p-value:

1.83e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032784

Regulation of DNA-templated transcription, elongation

7 of 21

2.43

5.76

1.57e-12

GO:0032786

Positive regulation of DNA-templated transcription, elongation

6 of 19

2.41

4.81

2.09e-10

GO:0034243

Regulation of transcription elongation from RNA polymerase II promoter

3 of 14

2.24

2.06

0.00011

GO:0031401

Positive regulation of protein modification process

3 of 31

1.89

1.56

0.00070

GO:0010604

Positive regulation of macromolecule metabolic process

7 of 292

1.29

1.48

1.57e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016538

Cyclin-dependent protein serine/threonine kinase regulator activity

3 of 16

2.18

1.41

0.0021

GO:0061575

Cyclin-dependent protein serine/threonine kinase activator activity

2 of 3

2.73

1.08

0.0108

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

2 of 5

2.51

1.08

0.0108

GO:0004693

Cyclin-dependent protein serine/threonine kinase activity

2 of 12

2.13

0.84

0.0278

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019908

Nuclear cyclin-dependent protein kinase holoenzyme complex

5 of 5

2.91

5.43

7.41e-11

GO:0000307

Cyclin-dependent protein kinase holoenzyme complex

6 of 18

2.43

5.03

7.41e-11

GO:0008023

Transcription elongation factor complex

6 of 19

2.41

5.0

7.41e-11

GO:0032806

Carboxy-terminal domain protein kinase complex

5 of 14

2.46

4.57

9.51e-10

GO:0008024

cyclin/CDK positive transcription elongation factor complex

4 of 4

2.91

4.44

6.10e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1689

RNA Polymerase II Pre-transcription Events, and RNA polymerase core enzyme binding

10 of 80

2.0

5.86

1.17e-16

CL:1833

cyclin/CDK positive transcription elongation factor complex, and Glucose receptor Git3, N-terminal

5 of 7

2.76

5.08

2.52e-10

CL:1768

RNA Polymerase II Transcription Elongation

4 of 28

2.06

2.44

1.03e-05

CL:1690

RNA polymerase II, holoenzyme, and RNA polymerase core enzyme binding

5 of 71

1.76

2.27

4.73e-06

CL:1772

RNA polymerase II, core complex

3 of 11

2.34

2.13

9.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6796648

TP53 Regulates Transcription of DNA Repair Genes

9 of 40

2.26

6.92

1.08e-16

MAP-674695

RNA Polymerase II Pre-transcription Events

9 of 67

2.04

5.61

3.71e-15

MAP-75955

RNA Polymerase II Transcription Elongation

6 of 43

2.05

3.93

1.41e-09

MAP-6807505

RNA polymerase II transcribes snRNA genes

7 of 75

1.88

3.75

3.19e-10

MAP-113418

Formation of the Early Elongation Complex

5 of 32

2.1

3.43

4.92e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008024

cyclin/CDK positive transcription elongation factor complex

5 of 6

2.83

5.24

1.46e-10

GOCC:0032806

Carboxy-terminal domain protein kinase complex

6 of 18

2.43

5.01

8.54e-11

GOCC:0008023

Transcription elongation factor complex

6 of 22

2.34

4.83

1.19e-10

GOCC:0061695

Transferase complex, transferring phosphorus-containing groups

8 of 150

1.63

3.08

3.11e-10

GOCC:0005654

Nucleoplasm

7 of 236

1.38

1.93

2.98e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0195

Cyclin

2 of 7

2.36

1.05

0.0116

KW-0804

Transcription

3 of 109

1.35

0.67

0.0346

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00385

Domain present in cyclins, TFIIB and Retinoblastoma

2 of 10

2.21

0.84

0.0282

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