STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prpBMethylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. (306 aa)    
Predicted Functional Partners:
prpD
2-methylcitrate dehydratase.
 
 
 0.995
mmgD
2-methylcitrate synthase; Belongs to the citrate synthase family.
 0.984
citZ
Citrate synthase 2; Belongs to the citrate synthase family.
 0.964
aceB
Malate synthase A; Belongs to the malate synthase family.
   
 0.949
citB
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.888
aceA
Isocitrate lyase.
  
  
0.849
yngHB
Biotin/lipoyl attachment protein.
   
 0.848
sucD
Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
   
 0.848
pyk
Pyruvate kinase; Belongs to the pyruvate kinase family.
     
 0.815
acsA_1
Acetyl-coenzyme A synthetase.
  
 
 0.813
Your Current Organism:
Halobacillus dabanensis
NCBI taxonomy Id: 240302
Other names: CGMCC 1.3704, H. dabanensis, Halobacillus dabanensis Liu et al. 2005, Halobacillus sp. D-8, JCM 12772, strain D-8
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