node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SKB47118.1 | SKB65194.1 | SAMN05660776_1233 | SAMN05660776_2291 | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | Formate C-acetyltransferase. | 0.909 |
SKB47118.1 | SKB74817.1 | SAMN05660776_1233 | SAMN05660776_2790 | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.568 |
SKB47118.1 | fumC | SAMN05660776_1233 | SAMN05660776_0283 | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | Fumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.866 |
SKB47118.1 | purN | SAMN05660776_1233 | SAMN05660776_1469 | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.849 |
SKB47118.1 | purU | SAMN05660776_1233 | SAMN05660776_2327 | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.862 |
SKB65194.1 | SKB47118.1 | SAMN05660776_2291 | SAMN05660776_1233 | Formate C-acetyltransferase. | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | 0.909 |
SKB65194.1 | purU | SAMN05660776_2291 | SAMN05660776_2327 | Formate C-acetyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.889 |
SKB74817.1 | SKB47118.1 | SAMN05660776_2790 | SAMN05660776_1233 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Prokaryotic molybdopterin-containing oxidoreductase family, iron-sulfur binding subunit. | 0.568 |
SKB74817.1 | SKB74827.1 | SAMN05660776_2790 | SAMN05660776_2791 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.999 |
SKB74817.1 | gcvT | SAMN05660776_2790 | SAMN05660776_0668 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.909 |
SKB74817.1 | glyA | SAMN05660776_2790 | SAMN05660776_2503 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
SKB74817.1 | purU | SAMN05660776_2790 | SAMN05660776_2327 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.889 |
SKB74827.1 | SKB74817.1 | SAMN05660776_2791 | SAMN05660776_2790 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SKB74827.1 | folD | SAMN05660776_2791 | SAMN05660776_1897 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.497 |
SKB74827.1 | gcvT | SAMN05660776_2791 | SAMN05660776_0668 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.916 |
SKB74827.1 | glyA | SAMN05660776_2791 | SAMN05660776_2503 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.919 |
SKB74827.1 | purN | SAMN05660776_2791 | SAMN05660776_1469 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.903 |
SKB74827.1 | purU | SAMN05660776_2791 | SAMN05660776_2327 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.892 |
folD | SKB74827.1 | SAMN05660776_1897 | SAMN05660776_2791 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.497 |
folD | gcvT | SAMN05660776_1897 | SAMN05660776_0668 | 5,10-methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.963 |