node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATG9 | MGG_13509 | Q51WZ9 | G4N756 | Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Required for mitophagy. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machinerie [...] | Uncharacterized protein. | 0.781 |
GET1 | GET3 | A4RHX3 | A4QUI2 | Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | 0.997 |
GET1 | MGG_04856 | A4RHX3 | G4N2B6 | Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. | Protein transporter SEC61 subunit alpha. | 0.593 |
GET1 | MGG_08069 | A4RHX3 | G4MXS8 | Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. | Uncharacterized protein. | 0.663 |
GET1 | MGG_13509 | A4RHX3 | G4N756 | Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. | Uncharacterized protein. | 0.516 |
GET3 | GET1 | A4QUI2 | A4RHX3 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. | 0.997 |
GET3 | MGG_04856 | A4QUI2 | G4N2B6 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Protein transporter SEC61 subunit alpha. | 0.661 |
GET3 | MGG_08069 | A4QUI2 | G4MXS8 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Uncharacterized protein. | 0.995 |
GET3 | MGG_13509 | A4QUI2 | G4N756 | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | Uncharacterized protein. | 0.568 |
MGG_01470 | MGG_06985 | G4MSK5 | G4MNW7 | RECA_2 domain-containing protein. | RECA_2 domain-containing protein. | 0.982 |
MGG_01470 | MGG_13509 | G4MSK5 | G4N756 | RECA_2 domain-containing protein. | Uncharacterized protein. | 0.604 |
MGG_01470 | MGG_15576 | G4MSK5 | G4MU73 | RECA_2 domain-containing protein. | DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. | 0.784 |
MGG_01470 | MGG_16388 | G4MSK5 | G4MM95 | RECA_2 domain-containing protein. | Uncharacterized protein. | 0.659 |
MGG_04856 | GET1 | G4N2B6 | A4RHX3 | Protein transporter SEC61 subunit alpha. | Protein GET1; Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. | 0.593 |
MGG_04856 | GET3 | G4N2B6 | A4QUI2 | Protein transporter SEC61 subunit alpha. | ATPase GET3; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. S [...] | 0.661 |
MGG_04856 | MGG_05188 | G4N2B6 | G4N512 | Protein transporter SEC61 subunit alpha. | Uncharacterized protein. | 0.834 |
MGG_04856 | MGG_13509 | G4N2B6 | G4N756 | Protein transporter SEC61 subunit alpha. | Uncharacterized protein. | 0.495 |
MGG_05188 | MGG_04856 | G4N512 | G4N2B6 | Uncharacterized protein. | Protein transporter SEC61 subunit alpha. | 0.834 |
MGG_05188 | MGG_13509 | G4N512 | G4N756 | Uncharacterized protein. | Uncharacterized protein. | 0.431 |
MGG_06985 | MGG_01470 | G4MNW7 | G4MSK5 | RECA_2 domain-containing protein. | RECA_2 domain-containing protein. | 0.982 |