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glyA protein (Porphyromonas gingivalis W83) - STRING interaction network
"glyA" - Serine hydroxymethyltransferase in Porphyromonas gingivalis W83
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second shell of interactors
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (426 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine (362 aa)
 
  0.996
serB
Phosphoserine phosphatase (413 aa)
   
  0.994
folC
Folylpolyglutamate synthase (429 aa)
   
  0.991
gcvP
Glycine dehydrogenase (955 aa)
   
 
  0.988
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (296 aa)
   
  0.977
PG_1747
Ribose 5-phosphate isomerase B (145 aa)
   
      0.966
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (126 aa)
   
 
  0.951
fhs
Formate--tetrahydrofolate ligase (555 aa)
   
  0.943
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase (508 aa)
   
 
  0.936
thyA
Thymidylate synthase; Provides the sole de novo source of dTMP for DNA biosynthesis (267 aa)
   
 
  0.908
Your Current Organism:
Porphyromonas gingivalis W83
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
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