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lepA protein (Porphyromonas gingivalis W83) - STRING interaction network
"lepA" - GTP-binding protein LepA in Porphyromonas gingivalis W83
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second shell of interactors
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filled nodes:
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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lepAGTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (595 aa)    
Predicted Functional Partners:
pheS
phenylalanyl-tRNA synthetase subunit alpha (340 aa)
   
   
  0.835
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (361 aa)
 
   
  0.792
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity (528 aa)
   
   
  0.776
gidA
Glucose-inhibited division protein A; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (625 aa)
 
   
  0.769
obg
GTPase ObgE; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control (394 aa)
   
   
  0.767
der
GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis (437 aa)
   
 
  0.742
rpsQ
Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5’-end of 16S ribosomal RNA (84 aa)
   
   
  0.738
pheT
phenylalanyl-tRNA synthetase subunit beta (819 aa)
   
   
  0.731
aspS
aspartyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Asp) in a two-step reaction- aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) (587 aa)
 
   
  0.725
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (876 aa)
   
   
  0.711
Your Current Organism:
Porphyromonas gingivalis W83
NCBI taxonomy Id: 242619
Other names: P. gingivalis W83, Porphyromonas gingivalis W83, Porphyromonas gingivalis str. W83, Porphyromonas gingivalis strain W83
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